Value of dynamic plasma cell-free DNA monitoring in septic shock syndrome: A case report

Table 1 Laboratory data

Parameter	Normal range	On admission 27 July	HD 2, 28 July	HD 3, 29 July	HD 4, 30 July	HD 5, 31 July	HD 6, 1 August	HD 7, 2 August	HD 8, 3 August
Hemoglobin (g/L)	130-175	151	123	113	93	101	94	104	61
RBC (× 1012/L)	4.30-5.80	4.78	3.91	3.62	2.95	3.25	3.06	3.32	2.04
WBC (× 109/L)	3.50-9.50	2.38	14.57	29.40	12.11	10.21	8.54	1.00	0.43
NEUT (%)	40.0-75.0	83.2	96.6	97.6	86.3	73.7	11.5	61.0	2.4
LYMPH (%)	20.0-50.0	16.8	3.2	3.62	3.2	15.9	81.0	23.0	86.0
Platelets (× 109/L)	125-350	68	44	42	51	43	40	21	16
Glucose (mmol/L)	3.9-6.1	/	7.3	10.9	/	6.5	6.3	4.7	/
Sodium (mmol/L)	137-147	138.9	148.3	150.5	146.7	148.7	149.8	155.0	155.5
Potassium (mmol/L)	3.5-5.3	3.2	2.6	4.6	3.3	3.8	3.8	3.4	2.9
Calcium (mmol/L)	2.20-2.65	2.08	2.13	2.04	1.94	2.35	2.35	2.69	1.95
Total bilirubin (μmol/L)	6.0-22.0	42.0	67.9	65.6	/	69.1	98.3	93.9	51.3
AST (IU/L)	0-45	87.1	188.5	103.8	62	65.5	118.1	119.5	55.5
ALT (IU/L)	13-69	42.5	72.7	56.2	39.8	33.8	55.6	62.7	25.4
GGT (IU/L)	8-78	253	330.4	283.9	/	144.1	124	162.9	72.6
Alkaline phosphatase (IU/L)	38-126	88	62.8	88	/	107.4	99	182.6	57.2
LDH (IU/L)	140-271	411	626	559	/	402	/	417	295
Albumin (g/L)	40.0-55.0	/	39.5	43.1	/	47.5	/	47.6	44.0
Globulin (g/L)	20.0-40.0	/	16.1	22.9	/	20.8	/	28.0	15.5
Urea (mmol/L)	2.10-7.20	5.91	10.00	12.50	/	13.01	15.04	17.29	12.70
Creatinine (μmol/L)	44.0-132.0	110.8	143.3	147.3	/	80.6	84.4	74.8	110.8
Lactate (mmol/L)	0.5-1.6	9.5	3.5	2.9	/	3.9	5.3	4.1	> 15
Procalcito-nin (ng/mL)	0-0.05	35.30	96.50	10.74	2.82	1.22	0.99	1.15	8.11
C-reactive protein (mg/L)	0-10	/	> 90.00	/	> 90.00	/	/	/	> 90.00
Plasma cell-free DNA (ng/mL)	0-52.5					1359.4	1339.8	1278.4	1366.4

Boldface numbers denote figures out of the normal range. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma glutamyl transferase; HD: Day of hospitalization; LDH: Lactate dehydrogenase; RBC: Red blood cells; WBC: White blood cells.