Role of oxysterol-binding protein-related proteins in malignant human tumours

Table 1 Specific types and functions of different oxysterol binding protein-related proteins and their associations with malignant human tumours

Ref.	Type of ORP (protein)	Length (kDa)	Function	Ref.
Lehto et al[23], 2008	ORP3	110	Regulates cell adhesion and migration	[23,24]
Burgett et al[29], 2011	ORP4	85	Increases tumour cell invasion and metastasis	[25-31]
Koga et al[37], 2008	ORP5	40	Increases tumour cell invasion and metastasis	[37,39,41,42]
Lehto et al[54], 2004	ORP6	115	Regulates cell adhesion and migration	[9,52-55]
Goldfinger et al[22], 2007	ORP7	106	Regulates cell adhesion and migration	[22]
Zhong et al[57], 2015	ORP8	45	Regulates apoptosis	[57,58]
Ngo et al[17], 1998	ORP9	100	Maintains the functional integrity of the early secretory pathway	[17]
Koriyama et al[48], 2010	ORP10	130	Associated with high LDL cholesterol and high serum TAG levels	[20,48,49]
Bouchard et al[47], 2007	ORP11	85	High risks of cardiovascular disease	[47]