Castleman disease presenting with jaundice: A case report and review of literature

Table 1 Summary of reported cases of Castleman disease presenting with jaundice

Year	Age	Sex	Clinical features	Location	Clinical type	Histology	Managements	Outcomes	Ref.
2003	61	Male	Painless jaundice	Common hepatic duct	UCD	HV	Bile duct resection; Hepatobiliary reconstruction	3-mo follow-up	[25]
2005	48	Male	Jaundice; Right upper abdominal quadrant tenderness	Porta hepatis, along CBD and lesser curvature of stomach	UCD	HV	Cholecystectomy; Triple bypass comprising Roux-en-Y choledochojejunostomy, retrocolic gastro jejunostomy and enteroenterostomy	Symptom free after 9-mo follow-up	[19]
2007	50	Male	Jaundice; Right upper quadrant abdominal pain	Cervical, right hilar, subcarinal, subaortic, peripancreatic areas; Both sides of neck and mediastinum; Right supraclavicular area	MCD	HV	Corticosteroids	Mass shrank after 2-wk treatment	[24]
2009	76	Male	Pruritis; Jaundice	Chest and abdomen diffuse lymphadenopathy; Compressing common bile duct and cystic duct	MCD	PC	Exploratory laparotomy; Cholecystectomy; Corticosteroid therapy	Partially controlled	[18]
2011	41	Male	Weight loss; Obstructive jaundice	Right supradiaphragmatic and periportal nodes; Periceliac, pericaval and aortocaval lymph nodes	MCD	PC	Video-assisted thoracoscopic surgery; Prednisolone therapy with endoscopic resolution of the obstruction	Remained well without jaundice for at least 2 yr	[21]
2011	58	Female	Fast-progressive jaundice; Liver failure	Right axilla; Hepatic hilus; Splenic hilus; Retroperitoneal area	MCD	HV	Excision of axillary nodes; CT-guided fine-needle biopsy of perihepatic lesions; High-dose steroid therapy; External biliary drainage	Partially controlled after steroid therapy Relapsed Progressive multi-organ failure Irreversible clinical worsening to death	[22]
2014	53	Male	Jaundice; Lower limb phlebitis; Splenomegaly	Neck; Hepatogastric gap	MCD	Mixed	Surgical resection; Chemotherapy	Relapsed 11-mo follow-up	[26]
2014	41	Male	Mild jaundice; Abdominal distension	Hepatic portal	UCD	HV	Surgical resection	90-mo follow-up	[26]
2015	43	Male	Fatigue; Jaundice	Hepatoduodenal ligament	UCD	HV	Surgical resection	25-mo follow-up	[27]
2016	29	Male	Jaundice; Intermittent bowel obstruction	Retroperitoneal tumor in subhepatic space	MCD	HV	Surgical extirpation; Adjuvant oncological treatment	Not shown	[20]
2018	62	Female	Jaundice; Nausea; Vomiting	Surrounding retropancreatic portal vein and hepatic artery	UCD	PC	Pancreaticoduodenectomy	Not shown	[23]
2018	62	Female	Intermittent Jaundice	Between hepatoduodenal ligament and inferior vena cava	UCD	Mixed	Surgical resection	12-mo follow-up	Current study

UCD: Unicentric Castleman disease; MCD: Multicentric Castleman disease; HV: Hyaline vascular; PC: Plasmacytic; CT: Computed tomography.