Celiac crisis, a rare occurrence in adult celiac disease: A systematic review

Table 1 Celiac disease published cases – clinical characteristics

Index	No	Age, yr	Sex	Weight loss	BMI, kg/m2	Time from the CD diagnosis	Previous GFD/ compliance	Favorable evolution under GFD
[26]	1	43	F	20 kg/12 mo	14.7	3 yr	Yes, non-compliance	Yes
[22]	1	28	F	-	14.0	21 yr	Yes, non-compliance	-
[10]	1	26	F	-	-	0	No	Yes
[27]	1	24	F	4-5 kg/1 wk	17.5	0	No	Yes
[28]	1	69	M	No	-	0	No	Yes
[25]	1	46	F	-	-	0	No	Yes
[12]	1	31	F	14 kg/1 mo	17	0	No	Yes
[29]	1	43	M	35 kg/6 mo	11	0	No	Yes
[30]	2	82, 75	F, M	-, -	-, -	0, 0	No, No	Yes, Yes
[31]	1	64	F	10 kg	-	0	No	Yes
[32]	1	52	F	Yes	-	0	No	-
[33]	1	30	F	9 kg/1 mo	21.5	0	No	Yes
[34]	1	83	M	-	-	0	No	Yes
[35]	1	67	M	18 kg/6 mo	-	0	No	Yes
[16]	12	mean 58.9 (34-74)	8F/4M	12/12 (5-15 kg)	-	11/12 – 0	11/12 – No; 1/12 - Yes, non-compliance	12/12 – Yes; corticosteroids 6/12
[14]	1	26	F	-	-	0	No	Yes
[24]	1	50	F	-	-	0	No	Yes
[36]	1	23	F	-		0	No	Yes
[37]	1	58	M	20 kg/2 mo	-	0	No	Yes
[38]	1	49	F	35 kg/3 mo	-	-	No	Yes
[39]	1	56	F	15 kg	-	2 yr	Yes, non-compliance	Yes, corticosteroids
[40]	1	38	M	Yes	-	0	No	Yes
[41]	1	50	M	13 kg/2 mo	-	0	No	Yes
[15]	1	37	F	Yes	-	0	No	Yes
[13]	1	26	F	-	19.9	2 yr	Yes, non-compliance	Yes, prednisone
[42]	1	30	F	15 kg/3 yr	-	0	No	Yes
[8]	2	75, 55	M, F	Yes, -	14.7, -	0, 0	No, No	Yes
[43]	1	36	F	4 kg/9 d	16.3	0	No	Yes
[44]	1	58	M	15 kg	17.3	0	No	Yes

BMI: Body mass index; CD: Celiac disease; GFD: Gluten-free diet.

Table 2 Celiac disease published cases – paraclinical characteristics

Index	No	Diagnosis				Hemogram	Coagulation
		Biopsy	EMA	tTG	DGP/AGA
[26]	1	Yes, Marsh 3c	-	P, 608 U	-	Hb – L (7.8 g/dL), PLT – L	INR – H (2.1), aPTT – H (45 s)
[22]	1	Yes	P	P	P	-	-
[10]	1	Yes	-	P (> 100 U)	-	Hb – H (15.8 g/dL)	-
[27]	1	Yes, Marsh 3c	-	P (99 U/mL)	-	Hb – L (9.3 g/dL)	INR – H (3.2)
[28]	1	Yes	-	P (132 U)	-	Hb – L (4.8-12.2 g/dL)	INR – H (1.3)
[25]	1	Yes, Marsh 3c	-	P (48 U)	P/(39 U)	Hb – L (11.0 g/dL)	-
[12]	1	Yes	-	-	-	-	INR – H (3.5)
[29]	1	Yes, Marsh 4	-	P (19 UI/mL)	-	-	-
[30]	2	Yes	P (3+)	P (200 RU/mL)	-	Hb – L (8.1 g/dL), PLT – L (180000/dL)	-
		Yes	P (+1)	P (200 RU/mL)		Hb – L (7.6 g/dL), PLT – L (156000/dL)	-
[31]	1	Yes, Marsh 4	P	P (> 200 U/mL)	P	Hb – L (8.7 g/dL)	-
[32]	1	Yes	-	-	-	Hb – L	-
[33]	1	Yes	P (> 1/1280)	-	-	Hb – NR (12.3 g/dL)	-
[34]	1	Yes	P	N	-	-	-
[35]	1	Yes, Marsh 3	N	N	N	Hb – NR (12.4 g/dL), PLT – L (160000/dL)	-
[16]	12	Yes 12/12, ≥ Marsh 3a	-	P, 10/11	-	-	-
[14]	1	Yes, Marsh 3	P (92 U/mL)	-	P/(20 U/mL)	-	-
[23]	1	Yes	P (1:160)	P (15 EU/mL)	-	-	-
[36]	1	Yes, Marsh 3b	-	P (33.9 U/L)	P/(41.9 U/L)	Hb – NR, PLT – L (94000/dL)	-
[37]	1	Yes, Marsh 4	-	P (> 200 U/mL)	-	Hb – L (4.7 g/dL)	-
[38]	1	Yes, Marsh 3c	P	P	-	Hb – L (7.2 g/dL), PLT – L (257000/dL)	INR – H (> 1.5), aPTT – H (154 s)
[39]	1	Yes, Marsh 4	N	N	-	-	-
[40]	1	Yes, Marsh 3c	P (35.9 U)	P (20.6 U)	-	Hb – NR (15.2 g/dL)	INR – H (1.6)
[41]	1	Yes, Marsh 3	P (158.7)	P (> 200 U/mL)	-	Hb - L (9.4 g/dL)	-
[15]	1	Yes, Marsh 3	P	P	AGA P	Hb - L (8 g/dL)	-
[13]	1	Yes, Marsh 3c	-	P (23.4, positive > 12)	AGA P (27.4)	HT - L (18%)	PT < 10%
[42]	1	Yes, Marsh 3b	-	-	AGA P (IgA 63.4, IgG 111.1)	Hb - L	-
[8]	2	Yes, Marsh 3a; Yes, Marsh 3b	P; P	-	AGA N; AGA P	Hb - L (5.9 /dL); Hb - L (7.9 /dL)	PT prolonged (19 s); PT prolonged (18 s)
[43]	1	Yes, Marsh 3c	-	-	-	Hb - L	-
[44]	1	Yes, Marsh 3c	P (1:640)	P (142)	AGA P	Hb - L (11.6 g/dL)	INR – H (1.6)

L: Low; H: High; N: Normal; M: Masculine; Hb: Hemoglobin; P: Positive, N: Negative: NR: Normal ranges, HT: Hematocrit; AGA: Anti-gliadin antibodies; aPPT: Activated partial thromboplastin time; CD: Celiac disease; DGP: Anti-deamidated gliadin antibodies; EMA: Anti-endomysial antibodies; INR: International normalized ratio; PLT: Platelets; PT: Prothrombin time; tTG: Anti-tissue transglutaminase antibodies.