Human podocyte injury in the early course of hypertensive renal injury

Table 1 Clinical characteristics

Characteristics	Hypertension group (n = 18)	Control group 1 (n = 10)	P value
Gender			Not analyzed
Male	9	5
Female	9	5
Age (yr)	63.2 ± 10	60.1 ± 10.7	0.454
BMI (kg/m2)	23.9 ± 2.3	24 ± 1.6	0.969
Blood pressure (mmHg)
Systolic	184 ± 17 (142 ± 18)1	122 ± 8	0.000 (0.003)2
Diastolic	106 ± 10 (82 ± 13)1	64 ± 11	0.000 (0.001)2
Microalbuminuria	13.01 ± 8.9	3.0 ± 1.1	0.000
ACR (mg/g)	107 ± 53	28 ± 3	0.000
Serum creatinine (μmol/L)	66 ± 11	61 ± 8	0.248
eGFR (mL/min/1.73 m2)	92.8 ± 11.2	98.9 ± 12.3	0.192

¹Blood pressure under antihypertensive treatment;

²Blood pressure under treatment versus normal control group. Values are mean ± SD. P < 0.05 was considered statistically significant. BMI: Body mass index; ACR: Albumin-to-creatinine ratio.

Table 2 Expression of nephrin and CD2-associated protein in urinary sediments, n (%)

	Hypertension group (n = 18)	Control group 1 (n = 10)	P value
Nephrin	10 (55.6)	0 (0)	0.001
CD2AP	6 (33.3)	0 (0)	0.013
Nephrin and CD2AP	5 (27.8)	0 (0)	0.025

Values are positive rate. P < 0.05 was considered statistically significant. CD2AP: CD2-associated protein.