Copyright
©The Author(s) 2019.
World J Clin Cases. Sep 26, 2019; 7(18): 2722-2733
Published online Sep 26, 2019. doi: 10.12998/wjcc.v7.i18.2722
Published online Sep 26, 2019. doi: 10.12998/wjcc.v7.i18.2722
Table 1 Comparison of clinical data and laboratory indicators between the two groups, n (%)
TIA Group (n = 30) | Control Group (n = 204) | t/X2 Value | P-value | |
Age | 70.71 ± 10.92 | 65.93 ± 18.09 | 1.408 | 0.160 |
Gender (Male/Female) | 18/12 | 126/78 | 0.034 | 0.853 |
Family history | 4 (13.33) | 21(10.29%) | - | 0.5391 |
Hypertension | 30 (100) | 178 (87.25) | 4.301 | 0.038 |
Diabetes | 22 (73.33) | 104 (50.98) | 5.258 | 0.022 |
Hypercholesterolemia | 10 (33.33) | 69 (33.82) | 0.003 | 0.958 |
Smoking | 14 (46.67) | 104 (50.98) | 0.195 | 0.659 |
Alcoholism | 4 (13.33) | 21 (10.29) | - | 0.5391 |
DBIT (μmol/L) | 4.19 ± 1.08 | 3.98 ± 1.43 | 0.772 | 0.441 |
TBIL (μmol/L) | 10.96 ± 3.96 | 9.77 ± 3.28 | 1.805 | 0.072 |
UA (mmol/L) | 329.34 ± 84.39 | 337.09 ± 87.18 | 0.456 | 0.649 |
TG (mmol/L) | 1.18 ± 0.43 | 1.15 ± 0.47 | 0.330 | 0.742 |
TC (mmol/L) | 4.46 ± 1.20 | 4.29 ± 1.09 | 0.787 | 0.432 |
HDL-C (mmol/L) | 1.17 ± 0.32 | 1.22 ± 0.34 | 0.757 | 0.459 |
LDL-C (mmol/L) | 3.04 ± 0.95 | 2.89 ± 0.87 | 0.871 | 0.384 |
Hcy (μmol/L) | 8.37 ± 2.76 | 7.29 ± 2.27 | 2.364 | 0.019 |
FBG (mmol/L) | 6.97 ± 2.89 | 5.84 ± 2.58 | 2.205 | 0.028 |
Table 2 Comparison of ultrasound characteristics and wall shear stress data between the two groups
TIA Group (n = 30) | Control Group (n = 204) | t/X2 Value | P-value | ||
Plaque location | Common carotid artery | 8 | 51 | 0.046 | 0.977 |
Carotid sinus | 18 | 124 | |||
Internal carotid artery | 4 | 29 | |||
Plaque property | Hard plaque | 9 | 104 | 6.062 | 0.048 |
Soft plaque | 14 | 54 | |||
Mixed plaque | 7 | 46 | |||
Lumen stenosis rate (%) | 58.26 ± 13.28 | 44.29 ± 21.82 | 3.411 | 0.001 | |
PSV (cm/s) | 90.34 ± 9.23 | 87.12 ± 9.42 | 1.753 | 0.081 | |
EDV (cm/s) | 17.24 ± 5.12 | 15.93 ± 3.82 | 1.673 | 0.096 | |
Proximal end WSS (dyne/cm2) | 9.15 ± 2.27 | 7.29 ± 3.86 | 6.720 | 0.000 | |
Distal end WSS (dyne/cm2) | 7.42 ± 1.95 | 6.39 ± 1.74 | 2.980 | 0.003 |
Table 3 COX multivariate analysis of transient ischemic attack in patients with atherosclerosis during follow-up
B | SE | Wald | P-value | RR | 95%CI | ||
Lower limit | Upper limit | ||||||
Hypertension | 1.365 | 0.293 | 2.813 | 0.037 | 3.914 | 2.204 | 6.951 |
Diabetes | 1.462 | 0.428 | 3.792 | 0.026 | 4.316 | 1.865 | 9.986 |
Hcy | 0.492 | 0.245 | 3.988 | 0.022 | 1.635 | 1.012 | 2.643 |
FBG | 0.390 | 0.176 | 2.918 | 0.034 | 1.477 | 1.046 | 2.085 |
Plaque property | 1.786 | 0.496 | 7.294 | 0.000 | 5.968 | 2.257 | 15.777 |
Lumen stenosis rate (%) | 1.675 | 0.328 | 6.028 | 0.000 | 5.337 | 2.806 | 10.151 |
Proximal end WSS (dyne/cm2) | 0.783 | 0.272 | 5.885 | 0.000 | 2.187 | 1.283 | 3.727 |
Distal end WSS (dyne/cm2) | 0.459 | 0.482 | 1.125 | 0.192 | 1.582 | 0.615 | 4.069 |
Table 4 ROC curve analysis of potential indicators for predicting TIA
AUC | 95%CI | Cutoff point | Sensitivity (%) | Specificity (%) | |
FBG | 0.726 | 0.664-0.782 | 6.23 | 66.67 | 68.14 |
Hcy | 0.711 | 0.648-0.768 | 7.65 | 90.00 | 42.16 |
Lumen stenosis rate | 0.832 | 0.778-0.877 | 62.01 | 96.67 | 54.41 |
proximal end WSS | 0.884 | 0.831-0.917 | 8.05 | 73.33 | 95.51 |
- Citation: Liu QY, Duan Q, Fu XH, Jiang M, Xia HW, Wan YL. Wall shear stress can improve prediction accuracy for transient ischemic attack. World J Clin Cases 2019; 7(18): 2722-2733
- URL: https://www.wjgnet.com/2307-8960/full/v7/i18/2722.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v7.i18.2722