Primary malignant melanoma of the biliary tract: A case report and literature review

Table 1 Cases of patients with primary melanoma of common bile duct

Ref.	Age/sex	Clinical presentation	Tumour location	Metastasis at presentation	Treatment	Outcome
Zaide[9]	47/M	Jaundice	Proximal CHD	No	Cholecystectomy and resection of CHD	DFS (6 mo)
Carstens et al[10]	30/M	Jaundice; Abdominal pain	Distal CBD	No	Whipple resection	PD (liver); Expired (6 mo)
Deugnier et al[11]	34/F	Jaundice; Abdominal pain	LHD	No	Left hepatectomy with partial right hepatic and CBD resection	PD (skin and lymph nodes); Expired (18 mo)
Zhang et al[12]	58/M	Jaundice	CBD and gallbladder	No	Whipple resection	PD; Expired (48 mo)[13]
Washburn et al[13]	43/M	Jaundice; Abdominal pain; Loss of weight	CHD and RHD	No	Right hepatic lobectomy and cholecystectomy	DFS (11 mo)
Washburn et al[13]	45/M	Jaundice; Loss of weight	Distal CBD and ampulla	No	Whipple resection	DFS (72 mo)
Wagner et al[14]	48/M	Jaundice and acute cholecystitis	CBD	No	Whipple resection	PD (widespread metastases); Expired (9 mo)
González et al[15]	67/F	Jaundice; Abdominal pain	Proximal CHD	No	Extrahepatic BD resection	DFS (17 yr)
Bejarano et al[16]	47/M	Jaundice; Abdominal pain; Loss of weight	Distal CBD	Yes (gallbladder)	Chemotherapy; (dacarbacin + IFN2B, Carboplatin	PD (stomach, spleen, lymph nodes, subcutaneous kidney); Expired (23 mo)
Hoshi et al[17]	55/M	Jaundice	CHD	Unknown	Bile duct resection	PD; Expired (4 mo)
Agrawal et al[18]	26/M	Abdominal pain	Intrahepatic biliary tract	No	Hepatic segmentectomy (II-III)	DFS (72 mo)
Smith et al[19]	55/M	Jaundice	Distal CBD	No	Whipple resection	DFS (12 mo)
Addepally et al[20]	52/M	Jaundice; Abdominal pain; Loss of weight	CHD	No	BCS	PD (liver, lymph nodes, mesentery and brain) Expired (3 mo)
Present case	51/M	Jaundice	CHD	No	Cholecystectomy and CHD resection PD (lung): Lung segmentectomy + nivolumab	PD (lung, 12 mo); OS (31 mo)

BCS: Best care support; CBD: Common bile duct; CHD: Common hepatic duct; DFS: Disease-free survival; F: Female; LHD: Left hepatic duct; M: Male; OS: Overall survival; PD: Progressive disease; RHD: Right hepatic duct.