ALK-positive anaplastic large cell lymphoma presenting multiple lymphomatous polyposis: A case report and literature review

Table 1 Results of laboratory examinations on admission

WBC	21.5 × 109/L	TP	5.8 g/dL
St	3%	Alb	2.3 g/dL
Seg	73%	GOT	117 IU/L
Lym	16%	GPT	252 IU/L
Mon	4%	LDH	275 IU/L
Eos	4%	ALP	753 IU/L
RBC	3.99 × 1012/L	γ-GTP	170 IU/L
Hb	12.1 g/dL	T-Bil	0.2 mg/dL
Hct	36.3%	CRP	13.00 mg/dL
Plt	695 × 109/L	s-IL-2R	12500 U/mL

St: Stab; Seg: Segmented; Lym: Lymphocytes; Mon: Monocytes; Eos: Eosinophil; Hb: Hemoglobin; Hct: Hematocrit; TP: Total protein; sIL-2R: Soluble interleukin-2 receptor.

Table 2 Clinical features of gastrointestinal anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

Case	Age / sex	Ref.	Occurrence site	Gross/ Endoscopic findings	ALK staining pattern	2p23(FISH /RT-PCR)	Treatment	Outcome
1	56/M	[12]	Esophagus	Large mass	Cytoplasmic		chemo. + auto-SCT	Alive (3 mo)
2	34/F	[13]	Esophagus	Fungating tumor	Nuclear and cytoplasmic		chemo. + auto-SCT	Alive (24 mo)
3	37/M	[14]	Esophagus	Submucosal mass	Nuclear and cytoplasmic		resection + chemo.	Alive (14 mo)
4	3/M	[15]	Esophagus	Wall thickening	Nuclear and cytoplasmic		chemo.	(undescribed)
5	53/M	[11]	Stomach	(Undescribed)	Cytoplasmic		resection + chemo.	Alive (84 mo)
6	72/F	[16]	Stomach	(Undescribed)	(Undescribed)	+ (FISH)	resection	Alive (84 mo)
7	36/M	[17]	Duodenum	(Undescribed)	Nuclear and cytoplasmic	+ (RT-PCR)	resection + chemo.	Alive (24 mo)
8	21/M	[18]	Stomach and Duodenum	Submucosal tumor	Nuclear and cytoplasmic		chemo.	(undescribed)
9	10/M	[11]	Small intestine	(Undescribed)	Nuclear and cytoplasmic		resection + chemo.	Alive (75 mo)
10	17/M	[19]	Jejunum	Polypoidal mass	Cytoplasmic		resection + chemo.	Alive (18 mo)
11	32/M	[20]	Jejunum/Ileum (junction)	Massive tumor	Nuclear and cytoplasmic		resection + chemo.	Alive (5 mo)
12	43/M	Our case	Stomach and Duodenum	MLP and gastric mocosal thickening	Nuclear and cytoplasmic		chemo.	Alive (22 mo)

ALK: Anaplastic lymphoma kinase; FISH: Fluorescence in situ hybridization; RT-PCR: Reverse transcription polymerase chain reaction; chemo.: Chemotherapy; auto-SCT: Autologous stem cell transplantation.