Myocardial bridge-related coronary heart disease: Independent influencing factors and their predicting value

Table 1 Comparison of clinical characteristics between the coronary heart disease group and the control group, n (%)

Characteristic	CHD group (n =1060)	Control group (n = 658)	t/X2 value	P-value
Age	60.25 ± 13.25	52.65 ± 10.86	12.360	0.000
Gender (Male/Female)	592/468	388/270	1.610	0.204
Family history of CHD	215 (20.3)	113 (17.2)	2.542	0.111
Hypertension	707 (66.7)	352 (53.5)	29.929	0.000
Diabetes	424 (40.0)	102 (15.5)	114.702	0.000
Smoking	286 (27.0)	122 (18.5)	15.970	0.000
ST-segment changes	456 (43.0)	72 (10.9)	196.224	0.000
Abnormal TC	445 (42.0)	264 (40.1)	0.579	0.447
Abnormal LDL-C	583 (55.0)	260 (39.5)	38.960	0.000
Abnormal HDL-C	456 (43.0)	270 (41.0)	0.656	0.418
Abnormal TG	472 (44.5)	289 (43.9)	0.061	0.805
Abnormal Lp(a)	311 (29.3)	182 (27.7)	0.560	0.454
Abnormal HCY	225 (21.2)	115 (17.5)	3.595	0.058
Abnormal PAY-1	178 (16.8)	99 (15.0)	0.916	0.339
Abnormal fibrinogen	157 (14.8)	87 (13.2)	0.842	0.359
Combined MB	235 (22.2)	53 (8.1)	57.969	0.000

CHD: Coronary heart disease; MB: Myocardial bridge; TC: Total cholesterol; TG: Triglyceride; LDL-C: Low-density lipoprotein cholesterol; Lp(a): Lipoprotein(a); HCY: Homocysteine; PAI-1: Plasminogen activator inhibitor-1.

Table 2 Multivariate logistic regression analysis factors affecting the development of coronary heart disease

Risk factor	B	SE	Wald	P	OR	95%CI
						Lower limit	Upper limit
Age	0.622	0.127	3.902	0.048	1.863	1.452	2.390
Hypertension (Yes = 1, No = 0)	1.831	0.227	9.824	0.001	6.238	3.998	9.734
Diabetes (Yes = 1, No = 0)	1.450	0.127	6.205	0.012	4.263	3.324	5.468
Smoking (Yes = 1, No = 0)	0.257	0.228	0.245	0.089	1.293	0.827	2.022
ST-segment changes (Yes = 1, No = 0)	0.638	0.311	5.079	0.023	1.892	1.028	3.481
LDL-C (Abnormal = 1, Normal = 0)	0.790	0.384	4.357	0.036	2.204	1.038	4.678
MB (with = 1, without = 0)	1.260	0.012	10.262	0.000	3.524	3.442	3.608

LDL-C: Low-density lipoprotein cholesterol; MB: Myocardial bridge.

Table 3 Comparison of myocardial bridge parameters between the myocardial bridge-coronary heart disease subgroup and the simple myocardial bridge subgroup

Parameter	Group		t/X2 value	P-value
	MB-CHD subgroup (n = 236)	Simple MB subgroup (n = 52)
MB type (Superficial /Deep)	125/111	38/14	7.016	0.008
Systolic compression (%)	50.28 ± 11.24	39.86 ± 12.08	7.326	0
Diastolic compression (%)	34.25 ± 10.20	24.74 ± 10.75	7.424	0
MCA systolic stenosis rate (%)	44.35 ± 9.43	32.92 ± 6.60	10.865	0

MB: Myocardial bridge; MCA: Mural coronary artery; CHD: Coronary heart disease.

Table 4 Multivariate analysis of independent influencing factors of myocardial bridge-related coronary heart disease

	B	SE	Wald	P	OR	95.0%CI
						Lower limit	Upper limit
MB type (Deep = 1, Superficial = 0)	0.459	0.316	2.858	0.072	1.582	0.852	2.939
MB thickness	1.001	0.274	10.420	0.000	2.722	1.591	4.657
Systolic compression	0.514	0.162	12.341	0.000	1.672	1.217	2.297
Diastolic compression	1.266	0.347	18.226	0.000	3.548	1.797	7.004
MCA systolic stenosis rate	0.602	0.242	9.854	0.001	1.825	1.136	2.933

MB: Myocardial bridge; MCA: Mural coronary artery.

Table 5 Receiver operating characteristic curve analysis of myocardial bridge indexes for diagnosis of coronary heart disease

	AUC	95%CI	Cut-off point	Sensitivity	Specificity
MB thickness	0.814a	0.764 - 0.857	21.54 mm	78.43%	70.97%
Systolic compression	0.755a	0.701 - 0.803	45.04%	37.25%	99.46%
Diastolic compression	0.870a	0.826 - 0.907	48.65%	95.10%	68.28%
MCA systolic stenosis rate	0.795a	0.744 - 0.840	43.45%	77.45%	67.74%
Combination	0.959	0.925 - 0.972	0.275	97.06%	87.63%

^aP< 0.05 vs Combination. MB: Myocardial bridge; MCA: Mural coronary artery.

Table 6 Logistic regression analysis of the effect of the combination of the four indicators on myocardial bridge-related coronary heart disease

	B	SE	Wald	P	OR	95.0%CI
						Lower limit	Upper limit
Combination ( > 0.275 = 1, < 0.275 = 0)	2.770	0.226	9.752	0.001	15.953	10.244	24.844