Vestigial like family member 3 is a novel prognostic biomarker for gastric cancer

Table 1 Characteristics of gastric cancer patients according to vestigial like family member 3 expression status

Characteristic	Cases	High expression	Low expression	P-value
Age (yr)
≤60	97	47	50	0.548
>60	75	32	43
Gender
Female	101	43	58	0.369
Male	71	36	35
Differentiation
Well	84	40	44	0.779
Poor and moderate	88	39	49
T stage
T1/2	91	36	55	0.105
T3/4	81	43	38
N stage
N0/1	95	36	59	0.028
N2/3	77	43	34
TNM stage
I-II	119	48	71	0.041
III-IV	53	31	22
HER2
Negative	89	32	57	0.010
Positive	83	47	36

Table 2 Univariate and multivariate analyses of factors associated with overall survival

Characteristic	Univariate analysis			Multivariate analysis
	Hazard ratio	95%CI	P-value	Hazard ratio	95%CI	P-value
Age (yr)	0.83	0.55-1.26	0.389
Gender (Male vs Female)	1.31	0.87-1.96	0.194
Differentiation (Well vs Poor and moderate)	0.81	0.54-1.22	0.304
T stage (T3/4 vs T1/2)	1.16	0.77-1.73	0.484
N stage (N2/3 vs N0/1)	0.94	0.63-1.42	0.778
TNM stage (III/IV vs I/II)	1.27	0.82-1.97	0.283
HER2 (Positive vs Negative)	1.19	0.79-1.8	0.392
VGLL3 (High vs Low)	1.66	1.09-2.55	0.019	1.66	1.09-2.55	0.019

VGLL3: Vestigial like family member 3.