Case Report
Copyright ©The Author(s) 2018.
World J Clin Cases. Jan 16, 2018; 6(1): 1-5
Published online Jan 16, 2018. doi: 10.12998/wjcc.v6.i1.1
Table 1 CDH1 related cancer risks and International Gastric Cancer Linkage Consortium 8th workshop management recommendations
Gastric cancerLobular breast cancerColon cancer
Lifetime cancer risk80%60%Unknown
SurveillanceEGD surveillance in persons not willing to undergo prophylactic gastrectomyAnnual clinical breast examsColon cancer screening in HDGC families with colon cancer from age 40 or 10 yr younger than the youngest diagnosis of colon cancer
If CDH1 + with no evidence of cancer, EGD surveillance, usually starting at age 16 until time of prophylactic gastrectomy per IGCLC 7 guideline[11]Bilateral breast MRI starting at age 30Repeat colonoscopy at 3-5 yr intervals per IGCLC 7 guidelines[11]
TherapySuggest prophylactic gastrectomy between age 20-30 if CDH1 + without evidence of cancer Suggests gastrectomy if evidence of cancer regardless of ageProphylactic mastectomy not recommended, but may be considered on case by case basisNot available