Multiple perforations and fistula formation following corticosteroid administration: A case report

Table 1 Summary of cases of Churg-Strauss syndrome/eosinophilic granulomatosis with polyangiitis with digestive perforation in the English literature

Ref.	year	Age/sex	Initial symptoms	WBC (/mm3)	Eosino (%)	Hormone	Perforation	treatment	Histology	Second perforation	Prognosis
Ikoma et al[10]	2014	19/female	Asthma	24700	39	Yes	Ileum	Anastomosis	Transmural infiltration of numerous eosinophils with thrombosis and extensive involvement of small arteries	No	Alive
Kaul et al[11]	2014	58/male	Low-grade fever	94000	42	Yes	Ileo-caecal junction	Ileostomy	Transmural inflammation of sub-mucosal and serosal vessels with perivascular infiltrate comprising of lymphomononuclear cells and eosinophils	No	Alive
Assmann et al[12]	2014	32/male	Dyspnea, fatigue, fever and chest pain	-	5500/l	Yes + cyclophosphamide	Middle part of jejunum	Anastomosis	-	No	Alive
Assmann et al[12]	2014	36/male	Dyspnea, fatigue, fever and chest pain	-	4900/l	Yes + cyclophosphamide	Colon transversum	Anastomosis	Eosinophilic infiltration and thrombotic vessel occlusion	No	Alive
Çiledağ et al[8]	2012	35/male	Anorexia	-	35	Yes	Small intestine	Repair	-	No	Died
Venditti et al[13]	2011	69/male	Abdominal pain	-	-	Yes	Right and transverse colon	Ileostomy	Multiple ulcers, extravasal granulomas and mucosal pseudopolyps	No	Alive
Zanaboni et al[14]	2008	43/male	Asthma	32000	65	Yes	Small intestine	Anastomosis	Necrotizing ischemic vasculitis with inflammatory granulomatous infiltrates of lymphocytes, polymorphonuclear cells and eosinophils	Yes	Alive
Rolla et al[15]	2007	55/male	Asthma	15500	21	Yes	Ileum	Anastomosis	Granulomatous vasculitis with eosinophilic infiltration	No	Alive
Murakami et al[5]	2004	51/female	Asthma	27650	62	Yes	Ileum	Anastomosis	Angiitis of small vessels surrounded by eosinophilic infiltration and granuloma of the vessels	No	Died
Nagashima et al[16]	2002	67/male	Asthma	18500	65	Yes	Intestine	Anastomosis	Vasculitis in the small arteries and arterioles characterized by thrombotic occlusion with fibrinoid necrosis of the vascular wall and prominent inflammatory cell infiltration in the perivascular region	No	Alive
Nakamura et al[17]	2002	31/male	Epigastralgia	19700	40	Yes	Jejunum and ileum	Anastomosis	Multiple ulcerative lesions with remarkable eosinophilic infiltration and thrombosis obstruction of small vessels	No	Alive
Alvarez et al[18]	2002	64/female	Urticaria, recurrent rhinitis, and asthma	10000	34	Yes	Intestine	Anastomosis	Wall ulcerations, vascular thrombosis with fibrinoid necrosis, and eosinophilic infiltrates	Yes	Died
Kim et al[4]	2000	72/female	Asthma	6600	14	Yes	Sigmoid colon	Anastomosis	Ulceration with heavy infiltrations of eosinophils, neutrophils and lymphoplasma cells	-	-
Sharma et al[19]	1996	16/male	Low-grade, continuous fever and wheezing sounds in the chest	12600	70	Yes	Jejunum	Anastomosis	Necrotizing vasculitis with marked eosinophilic infiltration of medium-to-small blood vessels and extravascular granulomas	No	Died