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©2014 Baishideng Publishing Group Inc.
World J Clin Cases. Dec 16, 2014; 2(12): 859-865
Published online Dec 16, 2014. doi: 10.12998/wjcc.v2.i12.859
Published online Dec 16, 2014. doi: 10.12998/wjcc.v2.i12.859
Table 1 Head-to-head studies which included patients with asthma treated by subcutaneous and sublingual immunotherapy1
Ref. | Year | Study Design | Age | No of patients | Asthma symptom score | Medication score | Findings | ||||||
Before SIT | After SIT | Before SIT | After SIT | ||||||||||
SCIT | SLIT | SCIT | SLIT | LSCIT | SLIT | SCIT | SLIT | ||||||
Mungan et al[29] | 1999 | Single-blind, placebo controlled | Adults | SCIT (n = 10) SLIT (n =15) Placebo (n = 11) | 1.2 | 0.63 | 0.59 | 0.41 | 6.8 | 4.93 | 3.9 | 1.97 | Reduction in symptom scores with only SCIT Reduction in medication scores with both SCIT and SLIT |
Eifan et al[30] | 2010 | Open label, randomized, controlled | 5-10 | SCIT (n = 16) SLIT (n = 16) Pharmacotherapy (n = 16) | 0.9 ± 0.7 | 1.4 ± 1.5 | 0.4 ± 0.6 | 0.2 ± 0.4 | 2.4 ± 1.4 | 2.8 ± 1.2 | 1.7 ± 1.4 | 1.2 ± 0.9 | Reducttion in symptom and medication scores and visual analog scores with both SCIT and SLIT |
Keles et al[31] | 2011 | Open label, randomized, controlled | 5-12 | SCIT (n = 11) SLIT (n = 13) SCIT plus SLIT (n = 14) Pharmacotherapy (n = 12) | 0.25 | 0.12 | 0 | 0 | 0.52 | 0.69 | 0.06 | 0.23 | Reduction in symptom scores and visual analog scores with both SCIT and SLIT |
Yukselen et al[32] | 2012 | Randomized, double-blind, double-dummy, placebo-controlled | 6-14 | SCIT (n = 10) SLIT (n = 11) Placebo (n =10 ) | 2.4 | 3.7 | 1 | 2.7 | 2.3 | 2.3 | 1 | 1.7 | Only SCIT was found superior to placebo on reduction of symptom and medication scores |
- Citation: Yukselen A, Kendirli SG. Role of immunotherapy in the treatment of allergic asthma. World J Clin Cases 2014; 2(12): 859-865
- URL: https://www.wjgnet.com/2307-8960/full/v2/i12/859.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v2.i12.859