Efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases

Table 1 Basic features of studies included in the study

Ref.	Release year	Observation group	Control group	Time of therapy
Wang et al[15]	2015	Tripterygium wilfordii glycosides tablets (270 mg/d) + MTX (10 mg/wk)	MTX (10 mg/wk)	24 wk
Zhang et al[16]	2018	Tripterygium wilfordii glycosides tablets (360 mg/d) + MTX (10 mg/wk) + leflunomide (20 mg/wk)	MTX (10 mg/wk) + leflunomide (20 mg/wk)	12 wk
Long et al[17]	2019	Tripterygium wilfordii glycosides tablets (360 mg/d) + MTX (10 mg/wk)	MTX (10 mg/wk)	12 wk
Zhang et al[18]	2018	Tripterygium wilfordii glycosides tablets (360 mg/d) + MTX (10 mg/wk)	MTX (10 mg/wk)	12 wk
Fang et al[19]	2018	Tripterygium wilfordii glycosides tablets (360 mg/d) + MTX (10 mg/wk)	MTX (10 mg/wk)	12 wk
Zhang et al[20]	2019	Tripterygium wilfordii glycosides tablets (360 mg/d) + MTX (10 mg/wk) + salazopyridine (10 mg/wk)	MTX (10 mg/wk) + salazopyridine (10 mg/wk)	12 wk
Xie et al[21]	2019	Tripterygium wilfordii glycosides tablets (360 mg/d) + MTX (10 mg/wk)	MTX (10 mg/wk)	12 wk
Wang et al[22]	2018	Tripterygium wilfordii glycosides tablets (360 mg/d) + MTX (10 mg/wk)	MTX (10 mg/wk)	12 wk
Wang et al[23]	2018	Tripterygium wilfordii glycosides tablets (360 mg/d) + MTX (10 mg/wk)	MTX (10 mg/wk)	12 wk
Li et al[24]	2018	Tripterygium wilfordii glycosides tablets (360 mg/d) + MTX (10 mg/wk)	MTX (10 mg/wk)	12 wk
Hou et al[25]	2021	Tripterygium wilfordii glycosides tablets (360 mg/d) + Prednisone (0.5 mg/kg/d)	Prednesone (0.5 mg/kg/d)	24 wk

MTX: Methotrexate.

Table 2 Subgroup analysis results of Tripterygium wilfordii glycosides tablets combined with Western medicine in treatment of different rheumatic immune disease

Subgroup	Relative risk	95%CI	P value
Rheumatoid arthritis	1.12	1.02-1.24	< 0.05
Systemic lupus erythematosus	1.05	0.93-1.18	0.45
Sjögren's syndrome	1.10	0.98-1.24	0.10
Treatment duration (≤ 12 wk)	1.08	1.01-1.16	< 0.05
Treatment duration (> 12 wk)	1.05	0.95-1.15	0.30

Table 3 Comparison of adverse reactions associated with Tripterygium wilfordii glycosides tablets combined with Western medicine vs Western medicine alone

Adverse reaction (%)	Observation group (n = 513)	Control group (n = 513)
Leukopenia	0.39	1.36
Liver function impairment	0.19	0.19
Gastrointestinal reactions	2.53	3.70
Elevated transaminases	0.78	1.17
Oral ulcers	0.39	0.58
Bone marrow transplantation	0.19	0.19
Rash	0.19	1.17
Hair loss	——	0.19
Headache	0.19	0.19