Carcinosarcoma of the breast: Facing the challenge of a rare nosologic entity

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Jan 16, 2025 (publication date) through Nov 8, 2024

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Jan 16, 2025; 13(2): 99619
Published online Jan 16, 2025. doi: 10.12998/wjcc.v13.i2.99619

Table 1 Key points on histological and immunohistochemical markers for the diagnosis of breast carcinosarcoma

Key points on histological and immunohistochemical markers
Apparent presence of sarcomatous and epithelial components
Non-existent region of transition between the two elements
Atypia or active pleomorphic spindle cells
Inflammatory infiltration
Immunoreactivity for keratin and vimentin
Positivity for AE1/AE3 and CAM5.2
Positivity for specific membrane antigens (EMA), cytokeratins, DF3, MNF-116, pancytokeratin, CK7/19 and p63
Absence of HER-2 receptor positivity
Negativity for estrogen and progesteron receptors
Epidermal growth factor receptor (EGFR) gene amplification and overexpression
Positive expression of smooth-muscle actin, desmin, neuron-specific enolase, PGP 9.5, myoglobin and p53

Citation: Mastoraki A, Tsamopoulou M, Stamatis FK, Strimpakos A, Mouchtouri E, Panagi C, Mela E, Mastoraki S, Kechagias A, Schizas D. Carcinosarcoma of the breast: Facing the challenge of a rare nosologic entity. World J Clin Cases 2025; 13(2): 99619
URL: https://www.wjgnet.com/2307-8960/full/v13/i2/99619.htm
DOI: https://dx.doi.org/10.12998/wjcc.v13.i2.99619