Double plasma molecular adsorption system for Stevens–Johnson syndrome/toxic epidermal necrolysis: A case report

Table 1 Naranjo adverse drug reaction probability scale: Items and score

Question	Yes	No	Don’t know	Patient’s score
(1) Are there previous conclusive reports on this reaction?	+1	0	0	+1
(2) Did the adverse event appear after the suspected drug was administered?	+2	-1	0	+2
(3) Did the adverse reaction improve when the drug was discontinued, or a specific antagonist was administered?	+1	0	0	0
(4) Did the adverse reaction reappear when the drug was re-administered?	+2	-1	0	0
(5) Are there alternative causes (other than the drug) that could on their own have caused the reaction?	-1	+2	0	-1
(6) Did the reaction reappear when a placebo was given?	-1	+1	0	0
(7) Was the drug detected in the blood (or other fluids) in concentrations known to be toxic?	+1	0	0	0
(8) Was the reaction more severe when the dose was increased, or less severe when the dose was decreased?	+1	0	0	0
(9) Did the patient have a similar reaction to the same or similar drug in any previous exposure?	+1	0	0	0
(10) Was the adverse event confirmed by any objective evidence?	+1	0	0	+1

Scoring: > 9 = definite; ADR: 5–8 = probable; ADR: 1–4 = possible; ADR: 0 = doubtful ADR; Patient’s score = 3.