Safety and efficacy comparison of remimazolam and propofol for intravenous anesthesia during gastroenteroscopic surgery of older patients: A meta-analysis

Table 1 The characteristics of included studies

Ref.		Age (yr)	Gender (M/F)	ASA (I/II)	BMI (kg/m2)	No. of patients
Ye et al[20], 2023	Remimazolam	68. 67 ± 4.55	39/25	44/64	NM	64
	Propofol	68. 67 ± 4.55	36/29	48/65	NM	65
Tan et al[21], 2021	Remimazolam	66.4 ± 4.8	19/14	18/15	22.7 ± 3.0	33
	Propofol	66.2 ± 5.0	21/12	18/15	23.2 ± 3.0	33
Hu et al[22], 2022	Remimazolam	70.11 ± 7.37	69/104	20/144	22.75 ± 3.15	173
	Propofol	69.92 ± 7.57	72/101	26/140	22.73 ± 3.23	173
Liu et al[23], 2023	Remimazolam	67.5 ± 4.9	51/58	11/96	23.7 ± 3.0	107
	Propofol	67.5 ± 5.7	51/56	10/99	24.0 ± 2.6	109
Guo et al[24], 2022	Remimazolam	70.4 ± 3.9	25/14	7/32	23.0 ± 3.0	38
	Propofol	69.1 ± 4.0	22/16	7/31	23.0 ± 3.4	38
Lu et al[25], 2022	Remimazolam	70.6 ± 4.7	78/122	6/192	22.2 ± 2.5	200
	Propofol	70.1 ± 4.5	83/117	17/181	22.2 ± 2.3	200
Liu et al[26], 2021	Remimazolam	68.87 ± 2.58	54/61	37/78	25.35 ± 2.07	115
	Propofol	69.12 ± 2.75	58/59	46/71	24.75 ± 2.16	117

ASA: American Society of Anesthesiologists Score; BMI: Body mass index; NM: Not mentioned.

Table 2 Significant features of each group

Ref.		No. of patients	Hypotension	Respiratory depression	Injection pain	Bradycardia	PONV	Dizziness	Successful sedation rate	Time to discharge	Time to total alert
Ye et al[20], 2023	Remimazolam	64	9	1	0	7	NM	1	64	NM	9 ± 1.51
	Propofol	65	47	3	8	30	NM	3	65	NM	7.67 ± 2.27
Tan et al[21], 2021	Remimazolam	33	1	NM	NM	NM	NM	NM	NM	NM	3.82 ± 2.49
	Propofol	33	16	NM	NM	NM	NM	NM	NM	NM	4.33 ± 2.97
Hu et al[22], 2022	Remimazolam	173	56	17	1	3	1	NM	172	19.92 ± 6.34	15.09 ± 4.06
	Propofol	173	88	31	8	3	0	NM	173	19.55 ± 7.6	13.75 ± 4.22
Liu et al[23], 2023	Remimazolam	107	3	NM	NM	5	11	4	39	NM	NM
	Propofol	109	14	NM	NM	6	7	4	107	NM	NM
Guo et al[24], 2022	Remimazolam	38	6	2	0	NM	10	11	35	NM	NM
	Propofol	38	17	9	5	NM	8	14	36	NM	NM
Lu et al[25], 2022	Remimazolam	200	73	9	2	3	NM	NM	200	NM	9.8 ± 3.7
	Propofol	200	139	20	24	17	NM	NM	200	NM	9.3 ± 3.7
Liu et al[26], 2021	Remimazolam	115	15	0	4	6	103	NM	111	NM	NM
	Propofol	117	12	0	15	9	101	NM	117	NM	NM

PONV: Postoperative nausea and vomiting; NM: Not mentioned.