Paired box proteins as diagnostic biomarkers for endocervical adenocarcinoma

Table 1 Classification, embryogenesis, and tumorigenicity of paired box protein family proteins

Group in PAX family	Member in PAX family	Expression site during embryogenesis	Involvement in tumorigenicity
I	PAX1	Skeleton, thymus, pharyngeal pouch
	PAX9	Skeleton, teeth, thymus
	PAX2	Kidney, CNS	Bladder and renal cancers
II	PAX5	B cells, CNS	Lymphomas
	PAX8	Kidneys, thyroid gland, CNS	Thyroid, ovarian, and cervical cancers
III	PAX3	Neural crest, CNS, muscle	Melanoma, rhabdomyosarcoma
	PAX7	Same as above	Rhabdomyosarcoma
IV	PAX4	Pancreas, gut
	PAX5	Pancreas, gut, and eyes	Gastrointestinal cancers

CNS: Central nervous system; PAX: Paired box protein.