Assessment of early factors for identification or prediction severe acute pancreatitis in pregnancy

Table 1 Differences in etiology

Etiology	MAPIP, n = 24	SAPIP, n = 21	Test value	P value
Hypertriglyceridemia	6	12	χ2 = 4.890	0.0871
Biliary	7	4
Other causes	11	5

¹Pearson's χ² test. MAPIP: Mild acute pancreatitis in pregnancy; SAPIP: Severe acute pancreatitis in pregnancy.

Table 2 Differences during pregnancy stage

Pregnancy stage	MAPIP, n = 24	SAPIP, n = 21	P value
First trimester	2	2	0.2581
Second trimester	7	2
Late trimester	15	17

¹Fisher’s exact test. MAPIP: Mild acute pancreatitis in pregnancy; SAPIP: Severe acute pancreatitis in pregnancy.

Table 3 Differences in age, heart rate, and blood pressure

Factors	MAPIP, n = 24	SAPIP, n = 21	Test value	P value
Age in yr	28.82 ± 4.50	30.40 ± 4.10	t = 0.521	0.6051
Heart rate in bpm	88.0 (19.75)	120.0 (40.0)	z = -2.849	0.0042
Systolic blood pressure in mmHg	115.67 ± 11.89	119.57 ± 11.82	t = -1.102	0.2771
Diastolic blood pressure in mmHg	73.21 ± 9.48	76.24 ± 9.16	t = -1.087	0.2831

Data are n (%).

¹T-test of two independent samples.

²Mann–Whitney nonparametric test.

MAPIP: Mild acute pancreatitis in pregnancy; SAPIP: Severe acute pancreatitis in pregnancy.

Table 4 Comparison of the first laboratory biochemical indicators after admission

Factor	MAPIP, n = 24	SAPIP, n = 21	Test value	P value
RBC as × 1012	3.53 ± 0.48	3.95 ± 0.75	t = -2.275	0.028
HCT	33.40 ± 5.65	36.99 ± 5.14	t = -2.219	0.032
HGB in g/L	110.67 ± 17.49	127.71 ± 22.68	t = -3.003	0.004
RDW	13.45 (1.12)	13.80 (2.35)	z = -1.298	0.194
WBC as × 109	12.42 ± 5.02	15.08 ± 5.55	t = -1.688	0.099
NEUT as × 109	11.18 ± 4.81	14.66 ± 4.81	t = -2.422	0.02
NEUT%	83.84 ± 8.44	90.14 ± 3.52	t = -3.183	0.003
LYM as × 109	1.23 (0.46)	0.58 (0.51)	z = -3.141	0.002
NLR	8.12 (9.80)	27.43 (25.61)	z = -3.686	0
TG in mmol/L	2.63 (6.80)	19.05 (31.49)	z = -2.207	0.027
TC in mmol/L	5.26 (2.41)	14.32 (14.29)	z = -1.615	0.106
Ca in mmol/L	2.13 (0.15)	2.04 (0.38)	z = -0.854	0.393
AMY in U/L	387 (1450.00)	588 (763.60)	z = -0.375	0.707
BUN in mmol/L	3.06 (1.12)	2.16 (2.75)	z = -0.797	0.426
SCR in mg/dL	47.66 (13.17)	47.45 (17.55)	z = 0.046	0.946
GPT in U/L	8.90 (16.00)	8.30 (33.10)	z = -0.194	0.846
GOT (U/L)	17.85 (21.73)	18.00 (28.50)	z = -0.546	0.585
DBIL in μmol/L	3.25 (2.43)	3.40 (4.45)	z = -0.046	0.964
IBIL in μmol/L	7.42 (3.80)	7.46 (4.37)	z = -0.032	0.975

AMY: Amylase; BUN: Blood urea nitrogen; DBIL: Direct bilirubin; GOT: Glutamic oxaloacetic transaminase; GPT: Glutamic pyruvic transaminase; HCT: Hematocrit value; HGB: Hemoglobin; IBIL: Indirect bilirubin; LYM: Lymph; MAPIP: Mild acute pancreatitis in pregnancy; NEUT: Neutrophil; NEUT%: Neutrophil ratio; NLR: Neutrophil–lymphocyte ratio; RBC: Red blood cell; RDW: Red blood cell distribution width; SAPIP: Severe acute pancreatitis in pregnancy; SCR: Serum creatinine; TC: Total cholesterol; TG: Triglyceride; WBC: White blood cell.

Table 5 Logistic regression analysis of related factors

Factor	OR	95%CI	P value
Heart rate in bpm	1.052	1.016–1.090	0.004
Hemoglobin in g/L	1.046	1.009–1.048	0.014
NEUT%	1.179	1.043–1.333	0.009
LYM as × 109	0.095	0.019–0.483	0.005
NLR	1.121	1.045–1.202	0.001

CI: Confidence interval; LYM: Lymphocyte count; NEUT%: Neutrophil ratio; NLR: Neutrophil-lymphocyte ratio; OR: Odds ratio.

Table 6 Assessment of the effectiveness of relevant factors

Factors	AUC	95%CI	P value	Cutoff	Sensitivity, %	Specificity, %
HR in bpm	0.748	0.593-0.903	0.004	107.000	66.7	87.5
NEUT%	0.732	0.582-0.882	0.008	84.300	100	54.2
LYM as × 109	0.774	0.628-0.920	0.002	0.875	83.3	76.2
NLR	0.821	0.700-0.943	0.000	17.890	71.4	83.3

AUC: Area under the curve; CI: Confidence interval; HR: Heart rate; NEUT%: Neutrophil ratio; LYM: Lymphocyte count; NLR: Neutrophil–lymphocyte ratio.