Evaluating the role of interleukin-2 and interleukin-12 in pediatric patients with concurrent Mycoplasma pneumoniae and Epstein-Barr virus infections

Table 1 Comparison of general data among Mycoplasma pneumoniae group, coinfection group and control group

Group	n	Age	Male/female	CRP in mg/L	Fever in days
Coinfection	165	5.31 ± 2.09	79/86	35.36 ± 10.09e,f	8.16 ± 2.15f
MP	165	5.26 ± 2.06	89/76	25.26 ± 8.06e	5.16 ± 1.06
Control	165	5.19 ± 2.45	83/82	15.30 ± 4.09	-
F/t/χ2	-	0.031	0.632	219.653	9.863
P value	-	0.965	0.075	< 0.001	< 0.001

^eP < 0.001 vs control group.

^fP < 0.001 vs Mycoplasma pneumoniae (MP) group. Coinfection: Epstein-Barr virus coinfection in MP pneumonia; Control: Healthy children; CRP: C-reactive protein.

Table 2 Comparison of general data between poor prognosis group and non-poor prognosis group

Group	n	Age	Male/female	CRP in mg/L	Fever in days
Poor prognosis	56	5.31 ± 2.19	32/24	36.36 ± 9.09f	9.73 ± 2.84f
Non-poor prognosis	109	5.16 ± 2.56	61/48	29.16 ± 7.31	5.83 ± 1.84
t/χ2	-	0.231	0.684	2.546	3.858
P value	-	0.865	0.076	< 0.001	< 0.001

^fP < 0.001 vs non-poor prognosis group. CRP: C-reactive protein.

Table 3 Comparison of the serum interleukin-2 and interleukin-12 levels among Mycoplasma pneumoniae group, coinfection group and control group

Group	n	IL-2	IL-12
Coinfection	165	3.75 ± 0.95e,f	14.09 ± 3.95e,f
MP	165	2.76 ± 0.66e	23.75 ± 7.19e
Control	165	1.89 ± 0.53	38.21 ± 10.74
F	-	98.62	267.83
P value	-	< 0.001	< 0.001

^eP < 0.001 vs control group.

^fP< 0.001 vs Mycoplasma pneumoniae (MP) group. Coinfection: Epstein-Barr virus coinfection in MP pneumonia; Control: Healthy children; IL-2: Interleukin-2; IL-12: Interleukin-12.

Table 4 Comparison of the serum interleukin-2 and interleukin-12 levels between poor prognosis group and non-poor prognosis group

Group	n	IL-2	IL-12
Poor prognosis	56	4.63 ± 1.27f	11.26 ± 3.63f
Non-poor prognosis group	109	2.41 ± 0.53	18.47 ± 4.63
t	-	7.974	8.764
P value	-	< 0.001	< 0.001

^fP < 0.001 vs non-poor prognosis group.

Table 5 Logistic regression analysis of factors affecting poor prognosis in children with Epstein-Barr virus coinfection in Mycoplasma pneumoniae pneumonia

Variate	β	SE	Wald χ2	P value	OR	95%CI
IL-2	1.186	0.496	5.847	0.013	3.865	1.235-7.475
IL-12	1.074	0.426	6.194	0.012	0.384	0.156-0.836
CRP	0.516	0.319	2.496	0.136	1.858	0.843-3.285
Fever	0.173	0.264	0.395	0.586	1.124	0.656-2.184

CRP: C-reactive protein; IL-2: Interleukin-2; IL-12: Interleukin-12.