Study on the efficacy of early treatment with pirfenidone on the lung function of patients with idiopathic pulmonary fibrosis

Table 1 Comparison of the total effective rate of clinical treatment among the three groups

Group	Number of cases	Markedly effective	Effective	Invalid	Total effective rate
Observation group	60	28	30	2	96.67
Later treatment group	55	26	23	6	89.09
Control group	53	25	20	8	84.91
χ²					5.279
P value					0.509

Table 2 Incidence of adverse reactions (nausea, vomiting, anorexia) compared among the three groups of patients

Group	Number of cases	Nausea	Vomiting	Anorexia	Frequency of adverse reactions
Observation group	60	1	1	0	3.33
Later treatment group	55	2	1	2	9.09
Control group	53	3	3	3	16.98
χ²					5.864
P value					0.021

Table 3 Comparison of symptom scores among the three groups of patients

Group	Number of cases	Shortness of breath	Fatigue	Cough	Spontaneous perspiration
Observation group	60	0.54 ± 0.18	0.61 ± 0.21	0.62 ± 0.23	1.12 ± 0.43
Later treatment group	55	1.56 ± 0.21	1.66 ± 0.32	1.85 ± 0.11	1.84 ± 0.12
Control group	53	1.94 ± 0.52	2.45 ± 0.63	2.83 ± 0.92	2.05 ± 0.53
F value		289.83	278.74	215.92	91.95
P value		0.000	0.000	0.000	0.000

Table 4 Comparison of the levels of pulmonary function indicators among the three groups

Group	Number of cases	Forced expiratory volume in 1 s in L	Forced vital capacity in L	Ratio of forced expiratory volume in one second to forced vital capacity
Observation group	60	3.56 ± 0.32	4.88 ± 0.44	79.39 ± 7.61
Later treatment group	55	3.14 ± 0.22	4.75 ± 0.13	70.36 ± 4.57
Control group	53	2.93 ± 0.21	4.15 ± 0.35	68.13 ± 6.41
F value		115.50	93.79	56.00
P value		0.000	0.000	0.000

Table 5 Comparison of inflammatory factor indicators among the two groups of patients

Group	Number of cases	C-reactive protein in mg/L	Interleukin-2 in ng/L	Interleukin-8 in ng/L
Observation group	60	9.11 ± 0.81	13.47 ± 1.02	20.11 ± 1.38
Later treatment group	55	11.21 ± 0.31	18.63 ± 0.99	26.31 ± 1.43
Control group	53	12.78 ± 1.12	19.57 ± 1.63	28.25 ± 2.51
F value		267.26	267.26	263.35
P value		0.000	0.000	0.000

Table 6 Comparison of the 6-min walking distance between the two groups of patients before and after therapy

Group	Number of cases	Before treatment	After treatment
Observation group	60	397.77 ± 30.22	420.69 ± 20.31
Later treatment group	55	398.21 ± 30.16	410.35 ± 21.67
Control group	53	398.61 ± 30.21	406.66 ± 23.33
F value		0.34	7.44
P value		0.711	0.001