Diagnosis and management of benign recurrent intrahepatic cholestasis and psychosocial stressors in an adolescent: A case report

Table 1 Genetic testing findings for ATP8B1 mutation

Gene	Chromosomal location	Transcription exons	Nucleotide amino acid	Hom/Het	Normal frequency	Pathogenicity analysis
ATP8B1	chr18:55351308-55351311	NM_005603; exon15	c.1587_1589delCTT (p.F529del)	Het	0.0001	Likely pathogenic

Table 2 Clinical data summary for each benign recurrent intrahepatic cholestasis episode

Attack	Date	Total bilirubin max (μmol/L)	ALP max (U/L)	GGT (U/L)	Treatment	Duration
1	October, 2019	93.1	265	Normal	UDCA, diammonium glycyrrhizinate	8 wk
2	April, 2020	64.5	156	Normal	UDCA, diammonium glycyrrhizinate	6 wk
3	August, 2020	279.0	151	Normal	UDCA, antihistamines, rifampicin,	11 wk
4	March, 2021	88.7	166	Normal	UDCA	6 wk

BRIC: Benign recurrent intrahepatic cholestasis; ALP: Alkaline phosphatase; GGT: -Glutamyl transferase; UDCA: Ursodeoxycholic acid.