Cytokine release syndrome triggered by programmed death 1 blockade (sintilimab) therapy in a psoriasis patient: A case report

Table 1 Patient abnormal laboratory values and reference value results

Laboratory test	Value at presentation	Reference value
Interleukin-2	0.97 pg/mL	≤ 9.80 pg/mL
Interleukin-4	1.98 pg/mL	≤ 3.00 pg/mL
Interleukin-6	631.25 pg/mL	≤ 16.60 pg/mL
Interleukin-10	12.93 pg/mL	≤ 4.90 pg/mL
TFN-α	2.36 pg/mL	≤ 5.20 pg/mL
Interferon-γ	66.89 pg/mL	≤ 17.3 pg/mL
CRP	232.94 mg/L	≤ 7 mg/L
Procalcitonin	0.25 ng/mL	≤ 0.5 ng/mL
ESR	60 mm/h	≤ 15 mm/h
APTT	49.4 s	26.0-40.0 s
INR	1.62	1.0-1.27
Fibrinogen1	6.73	2.0-4.0
Albumin	23.5 g/L	30-40 g/L
Rheumatoid factor	6.25 IU/mL	≤ 30 IU/mL
SARS-Co RNA	Negative	Negative
Influenza virus-A RNA	Negative	Negative
Influenza virus-B RNA	Negative	Negative
EB-Ab. IgM	Negative	Negative

¹With Clauss method.

TFN: Tumor necrosis factor; INR: International normalized ratio of prothrombin time; APTT: Activated partial thromboplastin time; EB-Ab: Epstein-Barr virus antibody; CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate.