Clinical efficacy of intradermal type I collagen injections in treating skin photoaging in patients from high-altitude areas

doi:10.12998/wjcc.v12.i16.2713

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Jun 6, 2024 (publication date) through Jun 29, 2024

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Clin Cases. Jun 6, 2024; 12(16): 2713-2721
Published online Jun 6, 2024. doi: 10.12998/wjcc.v12.i16.2713

Table 1 Inclusion and exclusion criteria

Inclusion criteria	Exclusion criteria
Age ≥ 18 yr, male or female	Pregnancy or lactation
Glogau photoaging score of II or III	Systemic diseases, such as diabetes, autoimmune diseases, and severe heart, liver, and kidney dysfunction
Residing in areas with an altitude of ≥ 1800 m for > 10 yr	Current treatment with glucocorticoids, estrogen, and other drugs that may cause facial pigmentation and affect the experimental results
Voluntarily receiving intradermal injection of Sunmax Col for facial rejuvenation and signing informed consent forms	Facial laser, freezing, and other treatments within the past 3 months
	Facial filling or botulinum toxin injection within the past 6 months
	Known allergies to Col or other ingredients in Sunmax Col
	Failure to follow up as planned or data loss affecting the evaluation of efficacy

Table 2 Face-Q scale content

Scale name	Content
Face-Q-Satisfaction with Facial Appearance Overall	Evaluates overall facial appearance
Face-Q-Satisfaction with Skin	Evaluates facial skin texture, color, and overall appearance
Face-Q-Satisfaction with Outcome	Evaluates the results of facial cosmetic treatments
Face-Q-Satisfaction with Decision	Evaluates decision-making regarding facial cosmetic treatments
Face-Q-Social Function	Evaluates the impact of facial appearance on social interactions
Face-Q-Psychological Function	Evaluates the psychological impact of facial appearance
Face-Q-Adverse Effects: Skin	Evaluates adverse reactions of the facial skin after treatment

Table 3 Comparison of skin thickness before and after intradermal injection of Col I (mm, mean ± SD)

	Baseline	1^st	2^nd	3^rd	4^th	5^th	6^th
Right cheek	1.65 ± 0.19	1.76 ± 0.22^a	1.88 ± 0.19^a	1.98 ± 0.16^a	2.04 ± 0.15^a	2.11 ± 0.17^a	2.15 ± 0.20^a
Left cheek	1.62 ± 0.21	1.69 ± 0.21	1.78 ± 0.19	1.90 ± 0.17^a	1.99 ± 0.12^a	2.06 ± 0.13^a	2.12 ± 0.16^a
Right zygomatic	1.57 ± 0.18	1.67 ± 0.20	1.79 ± 0.18^a	1.89 ± 0.16^a	1.96 ± 0.15^a	2.02 ± 0.14^a	2.08 ± 0.17^a
Left zygomatic	1.56 ± 0.22	1.63 ± 0.24	1.75 ± 0.23	1.86 ± 0.20	1.94 ± 0.18^a	2.01 ± 0.16^a	2.05 ± 0.15^a
Right temple	1.48 ± 0.25	1.54 ± 0.26	1.63 ± 0.24	1.75 ± 0.21	1.86 ± 0.18	1.96 ± 0.17^a	2.00 ± 0.20^a
Left temple	1.44 ± 0.24	1.52 ± 0.25	1.62 ± 0.26	1.73 ± 0.23	1.83 ± 0.20	1.94 ± 0.18^a	1.99 ± 0.16^a

^aP < 0.05, a statistically significant difference compared with before treatment.

Table 4 Comparison of VISIA parameters before and after intradermal injection of type I collagen (feature count, mean ± SD)

	Baseline	1^st	2^nd	3^rd	4^th	5^th	6^th
Red area	374.55 ± 22.89	325.25 ± 22.92^a	283.60 ± 23.08^a	244.35 ± 25.81^a	212.70 ± 28.48^a	189.85 ± 28.52^a	174.90 ± 27.18^a
Wrinkles	118.40 ± 16.43	114.80 ± 16.26	111.60 ± 16.64	108.80 ± 16.39	106.45 ± 16.21	104.30 ± 15.48	102.20 ± 15.29^a

^aP < 0.05, a statistically significant difference compared with before treatment.

Table 5 Comparison of Face-Q-Satisfaction with Facial Appearance Overall and Face-Q-Satisfaction with Skin scores before and after intradermal injection of type I collagen (mean ± SD)

	Baseline	1^st	2^nd	3^rd	4^th	5^th	6^th
Face-Q-Satisfaction with Facial Appearance Overall	40.05 ± 15.03	49.50 ± 14.86^a	57.50 ± 14.14^a	64.50 ± 12.47^a	72.50 ± 10.47^a	76.50 ± 9.56^a	80.40 ± 8.16^a
Face-Q-Satisfaction with Skin	34.05 ± 11.98	45.5 ± 12.33^a	55.25 ± 11.91^a	63.5 ± 9.73^a	73.6 ± 8.69^a	78.35 ± 8.11^a	82.40 ± 6.72^a

^aP < 0.01, a statistically significant difference compared with before treatment.

Table 6 Face-Q-Satisfaction with Outcome, Face-Q-Satisfaction with Decision, Face-Q-Social Function, Face-Q-Psychological Function, and Face-Q-Adverse Effects: Skin scores after 6 intradermal injections of type I collagen (mean ± SD)

Scale	Score
Face-Q-Satisfaction with Outcome	67.05 ± 15.50
Face-Q-Satisfaction with Decision	83.8 ± 14.50
Face-Q-Social Function	76.5 ± 8.7
Face-Q-Psychological Function	78.75 ± 7.5
Face-Q-Adverse Effects: Skin	13.85 ± 3.82

Citation: Yang B, He A, Bu BB, Zhuo G, Zhou QZ, He JH, Liu L, Huang WL, Zhao X. Clinical efficacy of intradermal type I collagen injections in treating skin photoaging in patients from high-altitude areas. World J Clin Cases 2024; 12(16): 2713-2721
URL: https://www.wjgnet.com/2307-8960/full/v12/i16/2713.htm
DOI: https://dx.doi.org/10.12998/wjcc.v12.i16.2713