Efficacy and safety of carrimycin in ten patients with severe pneumonia following solid organ transplantation

Table 1 Clinical characteristics of 10 patients with severe pneumonia after solid organ transplantation

Recipient	Gender	Age	Type of transplanted organ	Transplant time
1	Male	46	Renal transplantation	27 d
2	Male	63	Renal transplantation	5 months
3	Female	34	Renal transplantation	13 months
4	Male	55	Liver transplantation	7 d
5	Male	56	Renal transplantation	4 months
6	Female	27	Renal transplantation	5 months
7	Female	55	Renal transplantation	3 months
8	Male	60	Renal transplantation	16 yr
9	Male	27	Renal transplantation	4 months
10	Female	40	Renal transplantation	7 yr

Table 2 Treatment protocols of 10 patients with severe pneumonia after solid organ transplantation

Recipient	Treatment protocols
1	Carrimycin + Vancocin + Levofloxacin
2	Carrimycin + Amphotericin B
3	Carrimycin + Caspofungin + Trimethoprim-sulfamethoxazole
4	Carrimycin + Meropenem + Linezolid + Caspofungin
5	Carrimycin + Ganciclovir + Moxifloxacin + Trimethoprim-sulfamethoxazole + Peramivir
6	Carrimycin + Caspofungin + Piperacillin sodium and tazobactam sodium + Imipenem + Trimethoprim-sulfamethoxazole
7	Carrimycin + Meropenem + Azithromycin + Caspofungin
8	Carrimycin + Moxifloxacin + Ganciclovir + Peramivir + Imipenem + Piperacillin sodium and tazobactam sodium + Tigecycline + Linezolid + Fluconazole
9	Carrimycin + Caspofungin + Trimethoprim-sulfamethoxazole + Imipenem + Moxifloxacin
10	Carrimycin + Imipenem + Ganciclovir + Voriconazole

Table 3 Pathogens of 10 patients with severe pneumonia after solid organ

Recipients	Pathogens
1	Legionnella + Corynebacterium striatum
2	Mucor
3	Pneumocystis jirovecii
4	Baumanii + Staphylococcus epidermidis
5	Pneumocystis jirovecii + Cytomegalovirus
6	Pneumocystis jirovecii
7	Haemophilus parainfluenzae + Mycoplasma
8	Acinetobacter + Coronavirus
9	Acinetobacter
10	Aspergillus

Table 4 Outcomes of 10 patients with severe pneumonia after solid organ transplantation

Recipient	Outcome of transplants	Clinical outcomes
1	Remove	Abandoning treatment
2	Normal	Cure
3	Normal	Death
4	Normal	Cure
5	Normal	Cure
6	Normal	Abandoning treatment
7	Normal	Cure
8	Normal	Cure
9	Normal	Cure
10	Normal	Cure

Table 5 Antibacterial spectrum of carrimycin found so far

Pathogens	Antimicrobial spectrum
Gram-positive bacterium	Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus digestae, Other Streptococcus, Staphylococcus aureus, Legionella pneumophila
Gram-negative bacterium	Haemophilus influenzae, Moraxella catarrh, Neisseria gonorrhoeae
Anaerobe	Digestococcus, Bacteroid, Clostridium, Prevotella, Propionibacterium
Atypical pathogens	Mycoplasma pneumoniae, Ureaplasma urealyticum, Chlamydia trachomatis, Chlamydia pneumonia