Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study

Table 1 Detailed information on genome-wide association studies

Ref.	Outcome	PMID	Sample size
			Cases	Controls
Bellenguez et al[17], 2022	Alzheimer’s disease	35379992	39106	401577
Watson et al[18], 2019	Anorexia nervosa	31308545	16992	55525
Schoeler et al[19], 2023	Anxiety disorder	37106081	282802
Demontis et al[20], 2023	Attention deficit hyperactivity disorder	36702997	38691	186843
Stahl et al[21], 2019	Bipolar disorder	31043756	20352	31358
Howard et al[22], 2019	Major depressive disorder	30718901	246363	561190
Cross-Disorder Group of the Psychiatric Genomics Consortium[23], 2019	Multiple disorders	31835028	232964	494162
IOCDF-GC, OCGAS[24], 2018	Obsessive-compulsive disorder	28761083	2688	7037
Nievergelt et al[25], 2019	Post-traumatic stress disorder	31594949	30000	170000
Trubetskoy et al[26], 2022	Schizophrenia	35396580	76775	243649

Table 2 Details of variance explained by the selected instruments and F-statistics for the mendelian randomization analysis based on the sample size of autoimmune diseases

Exposure/Outcome	SNPs	R2	F-statistic
Alcohol-related liver disease
Alzheimer’s disease	/	/	/
Anorexia nervosa, anxiety disorder, attention deficit hyperactivity disorder, bipolar disorder, major depressive disorder, multiple disorders, obsessive-compulsive disorder, post-traumatic stress disorder, schizophrenia	rs738408	0.11	57352.08
Non-alcoholic fatty liver disease
Alzheimer’s disease	rs28601761, rs3747207, rs73001065	0.04	35089.81
Anorexia nervosa, anxiety disorder, attention deficit hyperactivity disorder, bipolar disorder, major depressive disorder, multiple disorders, obsessive-compulsive disorder, post-traumatic stress disorder, schizophrenia	rs3747207, rs429358	0.02	26942.59

SNPs: Single nucleotide polymorphisms.