Non-improvement of atrophic gastritis in cases of gastric cancer after successful Helicobacter pylori eradication therapy

Table 1 Grading system for the Kyoto classification score

Parameter	Score
Atrophy	0	C0–CI according to Kimura-Takemoto classification
	1	CII–CIII
	2	OI–OIII
Intestinal metaplasia	0	None
	1	Within the antrum
	2	Up to corpus
Hypertrophy of gastrid folds	0	None
	1	Positive
Nodularity	0	None
	1	Positive
Diffuse redness	0	None
	1	Mild (with RAC)
	2	Severe

The score was evaluated by five parameters, with the total score as the sum of these five parameter scores. RAC: Regular arrangement of collecting venules.

Table 2 Modified atrophy score

Modified atrophy score	Kimura-Takemoto classification
0	C0
1	CI
2	CII
3	CIII
4	OI
5	OII
6	OIII

Table 3 Patients’ characteristics

Characteristics	Gastric cancer	Gastritis	P value
Number	30	30
Age (yr ± SD)	75.3	73.9	0.695
Sex (M:F)	21:9	17:13	0.422
Differentiation (tub1-2: Sig-por)	29:1
Depth (m: Sm)	30:0

SD: Standard deviation; tub1-2: Well to moderate differentiated adenocarcinoma; sig: Signet ring cell carcinoma; por: Poorly differentiated adenocarcinoma; m: Mucosa; Sm: Submucosa.

Table 4 Each parameter of the Kyoto classification at the time of onset of gastric cancer and three years before onset of gastric cancer

Parameters	1st EGD	2nd EGD	P value	1st EGD	2nd EGD	P value	1st EGD	2nd EGD	P value
	A			IM			H
GC	2	2	1	1.27 ± 0.74	1.27 ± 0.74	1	0.43 ± 0.09	0.50 ± 0.504	0.543
GA	1.9±0.305	1.9±0.305	1	0.8 ± 0.76	0.87 ± 0.78	0.326	0.37 ± 0.09	0.367 ± 0.490	0.184
P value	0.0415	0.0415		0.0192	0.046		0.605	0.281
	N			DR
GC	0.03 ± 0.183	0.03 ± 0.183	1	1.27 ± 0.83	0.5 ± 0.82	0.0004
GA	0.03 ± 0.183	0	0.326	0.95 ± 0.17	0.07 ± 0.37	0.0008
P value	1	0.326		0.017	0.012

A: Atrophy; IM: Intestinal metaplasia; H: Hypertrophy of gastric folds; N: Nodularity; DR: Diffuse redness; GC: Gastric cancer; GA: Gastritis; 1^st EGD: First esophagogastroduodenoscopy three years prior to diagnosis of gastric cancer; 2^nd EGD: Second esophagogastroduodenoscopy, gastric cancer diagnosed at that time.