Copyright ©The Author(s) 2024.
World J Clin Cases. Apr 26, 2024; 12(12): 2023-2030
Published online Apr 26, 2024. doi: 10.12998/wjcc.v12.i12.2023
Table 1 Strengths and weaknesses of existing approaches to predicting intensive care unit-acquired weakness
Clinical assessmentClinicians can use clinical signs and symptoms to assess the risk of ICUAW, which is a non-invasive and readily available methodClinical signs and symptoms may not be sensitive or specific enough to accurately predict ICUAW
Electrophysiological TestingElectrophysiological tests, such as electromyography and nerve conduction studies, can provide objective measures of muscle function and help diagnose ICUAWElectrophysiological tests are invasive, time-consuming, and may not be feasible in critically ill patients
BiomarkersBiomarkers, such as creatine kinase and myosin light chain, can indicate muscle damage and may be useful for diagnosing ICUAWBiomarkers are not specific to ICUAW and may be elevated in other conditions
Muscle ultrasoundMuscle ultrasound can provide information about muscle thickness and echogenicity, which can be altered in patients with ICUAWThe interpretation of ultrasound findings can be subjective, and the technique may be operator-dependent
Table 2 Variety of clinical and demographic variables collected from patients admitted to the intensive care unit
Patient profile and assessment
Demographic informationAge
Other demographic characteristics of the patient
Clinical characteristicsComorbidities
Severity of illness scores (e.g., APACHE II, SOFA)
Reason for ICU admission
Laboratory valuesCreatinine
Liver function tests
Complete blood count
Inflammatory markers
Vital signsHeart rate
Blood pressure
Respiratory rate
Medication and treatmentSedatives
Neuromuscular blocking agents
Other medications
Mechanical ventilationDuration of mechanical ventilation
Mode of ventilation
Ventilator settings
Muscle strength and functionAssessment of muscle strength (e.g., Medical Research Council scale, handgrip dynamometer)
Neurological statusGlasgow coma scale score
Neurological examination findings
Presence of delirium
Functional statusPre-ICU functional status (e.g., ability to perform activities of daily living)
OutcomesDevelopment of ICUAW
Duration of ICU stay
Duration of mechanical ventilation