Efficacy and safety of aspirin antiplatelet therapy within 48 h of symptom onset in patients with acute stroke

Table 1 Baseline characteristics of the patients

Characteristic	Aspirin group (n = 30)	No aspirin group (n = 30)	P value
Age, yr (mean ± SD)	67.5 ± 11.2	68.1 ± 10.4	0.80
Male sex, n (%)	17 (56.7)	16 (53.3)	0.41
Time from stroke onset to randomization, h [median (IQR)]	12 (8-16)	12 (9-15)	0.27
Stroke type, n (%)
Ischemic	25 (83.3)	24 (80)	0.77
Hemorrhagic	5 (16.7)	6 (20)	0.36
Stroke location, n (%)
Anterior circulation	20 (66.7)	18 (60)	0.64
Posterior circulation	5 (16.7)	6 (20)	0.43
Lacunar	5 (16.7)	6 (20)	0.43
NIHSS score at admission, points (mean ± SD)	8.3 ± 4.2	8.7 ± 4.5	0.69
Medical history, n (%)
Hypertension	22 (73.3)	21 (70)	0.82
Diabetes mellitus	10 (33.3)	11 (36.7)	0.51
Dyslipidemia	12 (40)	13 (43.3)	0.38
Coronary artery disease	8 (26.7)	9 (30)	0.67
Atrial fibrillation	6 (20)	7 (23.3)	0.31
Previous stroke or TIA	4 (13.3)	5 (16.7)	0.42

IQR: Interquartile range; NIHSS: National Institutes of Health Stroke Scale; TIA: Transient ischemic attack.

Table 2 Primary outcome and its components

Outcome	Aspirin group (n = 30)	No aspirin group (n = 30)	Relative risk (95%CI)	P value
Primary outcome, n (%)	2 (6.7)	5 (16.7)	0.40 (0.12-1.31)
Recurrent stroke, n (%)	1 (3.3)	3 (10)	0.33 (0.04-2.76)	0.31
Myocardial infarction, n (%)	1 (3.3)	1 (3.3)	1.00 (0.07-14.42)	1.00
Vascular death, n (%)	1 (3.3)	2 (6.7)	0.50 (0.05-4.79)	0.55

95%CI: 95% confidence interval.

Table 3 Secondary outcomes

Outcome	Aspirin group (n = 30)	No aspirin group (n = 30)	P value
mRS score at 90 d, median (IQR)	2 (1-3)	3 (2-4)	0.04
Bleeding complications, n (%)	2 (6.7)	2 (6.7)	1.00
Intracranial hemorrhage, n (%)	0 (0)	0 (0)	-
Gastrointestinal bleeding, n (%)	0 (0)	0 (0)	-
Other major bleeding, n (%)	2 (6.7)	2 (6.7)	-
Mortality rate, n (%)	3 (10)	4 (13.3)	0.69

IQR: Interquartile range; mRS: Modified Rankin Scale.