Clinical study of NFNC in the treatment of acute exacerbation chronic obstructive pulmonary disease patients with respiratory failure

Table 1 Comparison of the general information patients in the two groups

Group	Gender (Male/Female)	Age (yr)	BMI (kg/m2)	Type of lung infection (n)
				Germ	Fungus	Mix	Others
Therapy group (40)	26/14	54.78 ± 3.09	25.01 ± 3.67	18	13	7	2
Control group (40)	27/13	54.62 ± 3.10	25.33 ± 3.65	20	14	3	3
χ2/t	0.056	0.231	0.391	0.201	0.056	1.829	0.213
P value	0.813	0.818	0.697	0.654	0.813	0.176	0.644

BMI: Body mass index.

Table 2 Summary of the levels of comfort in the two patient groups

Group		Nose discomfort	Pain	Chest discomfort	Throat discomfort
Control group (40)	Treatment 3 d difference	1.37 ± 0.38	0.56 ± 0.20	0.49 ± 0.15	1.24 ± 0.32
	Treatment 5 d difference	1.22 ± 0.34	0.41 ± 0.18	0.45 ± 0.12	1.01 ± 0.33
Therapy group (40)	Treatment 3 d difference	1.01 ± 0.22a	0.55 ± 0.19	0.30 ± 0.14a	0.68 ± 0.35a
	Treatment 5 d difference	0.89 ± 0.28a	0.37 ± 0.20	0.28 ± 0.15a	0.47 ± 0.25a

^aP < 0.05.

Compared with control group.

Table 3 Comparison of blood gas analysis between the two groups of patients before and after treatment

Group	PaO2 (mmHg)		PaO2/FiO2 (mmHg)		PaCO2 (mmHg)		SaO2 (%)
	Before treatment	After treatment	Before treatment	After treatment	Before treatment	After treatment	Before treatment	After treatment
Control group (40)	67.44 ± 7.23	93.27 ± 8.14	172.34 ± 11.25	291.81 ± 7.82	52.23 ± 6.57	39.67 ± 2.24	94.76 ± 3.15	96.45 ± 0.15
Therapy group (40)	67.40 ± 7.22	98.37 ± 8.20	172.31 ± 11.64	322.27 ± 7.81	52.24 ± 6.53	37.23 ± 2.26	94.75 ± 3.26	97.57 ± 0.16
t	0.025	2.792	0.012	17.431	0.007	4.850	0.014	32.298
P value	0.980	0.007	0.991	< 0.001	0.995	0.012	0.989	0.035

Table 4 Analysis of infection indicators in the two groups of patients

Group	White blood cell count (109/L)		C-reactive protein (g/L)		Calcitonin (g/L)
	Before treatment	After treatment	Before treatment	After treatment	Before treatment	After treatment
Control group (40)	11.38 ± 1.10	10.41 ± 1.16	23.41 ± 2.27	8.71 ± 1.56	1.57 ± 0.33	3.41 ± 0.32
Therapy group (40)	11.40 ± 1.08	8.44 ± 1.65	23.43 ± 2.25	6.50 ± 1.82	1.55 ± 0.37	5.64 ± 1.15
t	0.082	6.177	0.040	5.831	0.255	11.815
P value	0.935	0.017	0.965	< 0.001	0.799	0.003