Clinical pharmacists’ involvement in carbapenem antibiotics management at Wenzhou Integrated Hospital

Table 1 Drug usage, sales amount, and growth rate

Drug	Year	Drug usage and growth rate		Sales amount and growth rate
		Drug usage (g)	Growth rate (%)	Sales amount (ten thousand yuan)	Growth rate (%)
Imipenem-cilastatin sodium for injection	2019	3856	-	102.7903	-
	2020	2741	-28.92	64.7471	-37.01
	2021	1912	-30.24	43.8109	-32.34
Meropenem for injection (0.3 g)	2019	4168.5		123.1964
	2020	2136.3	-48.75	60.3083	-51.05
	2021	756.0	-64.61	19.3400	-67.93
Meropenem for injection (0.5 g)	2019	16142.5		210.1041
	2020	12712	-21.25	161.9921	-22.90
	2021	10797.5	-15.06	125.4313	-22.57

Table 2 Comparison of defined daily doses, drug utilization index, sales amount, and drug proportion for main carbapenem antibiotics

Year	Parameter	Imipenem-cilastatin sodium for injection (1 g)	Meropenem for injection (0.3 g)	Meropenem for injection (0.5 g)
	DDD (g)	2	1.5	3
	DDC (yuan)	259.1	410.7	203.64
2019	AUD	41	74	115
	Ranking	3	2	1
	DDDs	1928	3473.75	5380.83
	Ranking	3	2	1
	B/A	1.00	1.00	1.00
2020	AUD	27	8	85
	Ranking	2	3	1
	DDDs	1370.75	1780.25	4237.33
	Ranking	3	1	2
	B/A	0.67	3.00	0.50
2021	AUD	20	13	74
	Ranking	2	3	1
	DDDs	956	625	3599.17
	Ranking	3	2	1
	B/A	0.67	1.50	1.00

AUD: Antibiotic utilization density; DDC: Drug distribution code; DDDs: Defined daily dose.