Prognostic model of hepatocellular carcinoma based on cancer grade

Table 1 The least absolute shrinkage and selection operator Cox regression result

Gene	Description	Coefficient
KIF20A	Enables protein kinase binding activity. Involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis	0.207160352
CENPA	This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. The protein is a replication-independent histone that is a member of the histone H3 family	0.335103720
CDKN3	The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor	-0.037558302
FAM64A	Predicted to be involved in cell division	-0.134768381
KIF2C	This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation	0.187028347
CCNB2	Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, are essential components of the cell cycle regulatory machinery	-0.438267747
TTK	The protein encoded by this gene is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles	0.400136922
CYP26B1	This gene encodes a member of the cytochrome P450 superfamily. The encoded protein functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms	0.205800982
CYP4A22	This gene encodes a member of the cytochrome P450 superfamily of enzymes. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33	0.084476409
CYP2C8	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol	0.002430565
CYP1A2	This gene encodes a member of the cytochrome P450 superfamily of enzymes. It is able to metabolize some PAHs to carcinogenic intermediates	0.072320556
CYP2B6	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide	0.013546756
CYP2C9	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen, and S-warfarin	-0.117163123