Hepatic MR imaging using IDEAL-IQ sequence: Will Gd-EOB-DTPA interfere with reproductivity of fat fraction quantification?

Table 1 Baseline patient characteristics and treatment history

Demographics	Parameter	No. of patients (%)
Age	< 60 yr	51 (65)
	> 60 yr	28 (35)
Sex	Male	48 (60)
	Female	17 (40)
Cause	HBV	20 (30)
	HCV	9 (14)
	HBV and HCV	2 (3)
	Alcohol	25 (38)
	Cryptogenic	9 (14)
Cirrhosis	Present	35 (54)
	Absent	30 (46)
Methods of diagnosis	Biopsy	15 (23)
	MR imaging	50 (77)
Tumor characteristics	Unifocal	43 (66)
	Multifocal	22 (34)
Diameter of lesion	< 3 cm	42 (65)
	> 3 cm	23 (35)
No treatment		45 (69)
Treated	Surgical treatment	9 (14)
	Internal medicine	11 (17)

Numbers in parentheses are percentages, and percentages were rounded. HBV: Hepatitis B virus; HCV: Hepatitis C virus.

Table 2 Fat fraction and R2* (mean ± SD, n = 65) of the liver, spleen and spine at four time instants

Index	T1	T2	T3	T4
Liver FF	6.0567 ± 3.1295	6.0622 ± 3.1026	6.0928 ± 3.0863	6.103 ± 3.1272
Spleen FF	2.0183 ± 0.7687	2.0363 ± 0.7531	2.0478 ± 0.7633	2.0652 ± 0.7494
Spine FF	25.6275 ± 6.6189	25.6422 ± 6.5966	25.6495 ± 6.5979	25.6648 ± 6.5941
Liver R2*	43.1359 ± 9.95	48.211 ± 10.0155	49.5981 ± 10.0038	52.0894 ± 10.0021
Spleen R2*	42.9711 ± 13.9805	46.0781 ± 13.7729	46.3787 ± 13.7615	46.7647 ± 13.796
Spine R2*	121.7495 ± 20.602	124.902 ± 20.3045	125.7506 ± 20.263	126.4444 ± 20.3439

T1: Pre-contrast; T2: Between portal phase (70 s) and equilibrium phase (180 s); T3: Delayed phase (5 min); T4: Hepatobiliary phase (20 min).

Table 3 The comparison of fat fraction (n = 65) before and after hepatocyte-specific contrast media injection

Variation	DF	SS	MS	F	P value
T1-T2 (liver)	1	0.001	0.001	0.0319	0.8584
T1-T3 (liver)	1	0.0417	0.0417	1.3901	0.2399
T1-T4 (liver)	1	0.0685	0.0685	2.2825	0.1325
T1-T2 (spleen)	1	0.0103	0.0103	0.4911	0.4843
T1-T3 (spleen)	1	0.0328	0.0328	1.5601	0.2132
T1-T4 (spleen)	1	0.0703	0.0703	3.3418	0.0691
T1-T2 (spleen)	1	0.0069	0.0069	0.1703	0.6803
T1-T3 (spleen)	1	0.0157	0.0157	0.3859	0.5352
T1-T4 (spleen)	1	0.045	0.045	1.1053	0.2944

DF: Degree of freedom; SS: Variance; MS: Mean square; F: Statistics.

Table 4 The comparison of R2* (n = 65) before and after injection of Gadoxetate disodium

Variation	DF	SS	MS	F	P value
T1-T2 (liver)	1	297.9598	297.9598	476.8081	< 0.0001
T1-T3 (liver)	1	377.59	377.59	604.2357	< 0.0001
T1-T4 (liver)	1	492.3481	492.3481	787.8766	< 0.0001
T1-T2 (spleen)	1	299.2445	299.2445	1035.896	< 0.0001
T1-T3 (spleen)	1	359.9598	359.9598	1246.074	< 0.0001
T1-T4 (spleen)	1	446.1213	446.1213	1544.34	< 0.0001
T1-T2 (spleen)	1	313.126	313.126	317.1906	< 0.0001
T1-T3 (spleen)	1	504.28	504.28	510.826	< 0.0001
T1-T4 (spleen)	1	694.3318	694.3318	703.3447	< 0.0001

DF: Degree of freedom; SS: Variance; MS: Mean square; F: Statistics.