Case Report
Copyright ©The Author(s) 2023.
World J Clin Cases. Aug 26, 2023; 11(24): 5804-5810
Published online Aug 26, 2023. doi: 10.12998/wjcc.v11.i24.5804
Table 1 Summary of 10 malignant hidroacanthoma simplex cases
Case
Ref.
Age
Gender
Duration (yr)
Location
Size (cm)
Color
Ulceration
Clinical feature
Recurrence
1Sun Kim et al[2], 201269F1Suprapubic area2 × 2Pigmented(-)Verrucous noduleNo Recurrence
2Lee et al[3], 200671FNRRight knee1.8 × 2.0Pigmented(-)Hyperkeratotic tumorNR
3Ishida et al[10], 200972M3Right thigh1.7 × 1.2Brown to black(-)Flat plaqueLiver and bone metastases before surgery
4Bardach et al[4], 197870F15-20Right legNot mentionedRed(-)Irregularly shaped and crustedNR
5Yang et al[11], 202280M5Left foot1.2 × 0.8Black(-)Elevated noduleNo Recurrence
6Kohli et al[5], 201579MNRScalp0.6 × 0.5Pink(+)PapuleNo Recurrence
7Piqué et al[6], 199573F15Right leg3 × 3Pigmented(-)Verrucous lesionNR
8Ansai et al[7], 199475M2Right ankle2.5 × 3.3Pigmented(-)Verrucous plaqueNo Recurrence
9Lee et al[8], 200067F16Right thigh5 × 7Pigmented(-)Verrucous lesionNR
10Takano et al[9], 198974FNRLeft thigh1.5 × 1.5Light brown(+)Elevated noduleDied of cardiac and respiratory failure
Table 2 Histopathological and immunohistochemical features of 10 cases
Case
Intraepidermal nests
Sharp delineation
Hyperkeratosis or acanthotic epidermis
Invasive growth
Nuclear and cytoplasmic pleomorphisms
Mitotic figure
Ductal structure
Immunohistochemistry
1(+)(-)(+)(+)(-)(+)(+)EMA (+), CK10 (+), CK14(+)
2(+)(+)(-)(-)(-)(+)(-)EMA (+), CEA (+)
3(+)(+)(+)(+)(+)(+)(+)NR
4(+)(+)(+)(-)(-)(-)(+)NR
5(+)(+)(+)(-)(+)(+)(+)CK5/6 (+), P63 (+), CEA (-) CK7 (-)
6(+)(+)(+)(-)(+)(+)(+)CytokeratinAE1/3 (+), EMA (+), CEA (+), CK7 (+)
7(+)(+)(+)(-)(+)(+)(+)CAM5.2 (+), CEA (+), S100 (+), EMA (+)
8(+)(+)(+)(+)(+)(+)(-)NR
9(+)(+)(+)(+)(+)(-)(-)EMA (+), CEA (+), S100 (+)
10(+)(+)(-)(-)(+)(-)(-)NR