Tear inflammation related indexes after cataract surgery in elderly patients with type 2 diabetes mellitus

Table 1 Comparison of general information between two groups of patients

Groups	Age1 (yr)	Gender2 (M/F)	Visual acuity (BCVA)3			Intraocular pressure1 (mmHg)	HbA1c1 (%)	GA1 (%)	TG1 (mmol/L)	TC1 (mmol/L)
			≤ 0.1	0.1-0.3	≥ 0.3
Group A	69.3 ± 6.6	9/11	9	8	3	15.3 ± 2.28	8.2 ± 0.6	25.1 ± 4.8	2.0 ± 0.3	5.7 ± 0.4
Group B	71.0 ± 5.0	10/10	8	10	2	15.8 ± 2.76	5.4 ± 0.1	14.0 ± 1.5	1.7 ± 0.3	5.6 ± 0.4
χ2/F value	1.196	0.100		0.481		0.225	8.197	8.700	0.238	0.749
P value	0.557	0.752		0.829		0.575	0.002	0.020	0.458	0.142

¹The use of two independent samples t-test.

²The use of the χ² test.

³The use of Pearson’s χ² test.

HbA1c: glycated hemoglobin; GA: glycated albumin; TG: triglycerides; TC: total cholesterol.

Table 2 Comparison of matrix metalloproteinase-2 and matrix metalloproteinase-9 levels in the tears of two groups at different time points

Time	MMP-2 (ng/mL)				MMP-9 (ng/mL)
	Group A	Group B	t value	P value	Group A	Group B	t value	P value
Preoperative	11.13 ± 0.56	8.83 ± 0.88	11.65	0.000	36.07 ± 1.82	25.55 ± 1.74	13.22	0.000
1 d	10.71 ± 0.68	8.07 ± 0.68	10.54	0.000	42.90 ± 1.82	32.69 ± 2.33	10.96	0.000
3 d	13.53 ± 0.79	10.42 ± 0.96	11.06	0.000	43.37 ± 1.33	32.80 ± 1.02	18.09	0.000
1 wk	14.45 ± 0.9	10.54 ± 0.94	8.22	0.000	56.25 ± 1.96	43.02 ± 1.45	20.45	0.000
2 wk	13.17 ± 0.93	9.43 ± 0.49	12.29	0.000	72.78 ± 1.66	51.99 ± 1.71	41.48	0.000
3 wk	11.37 ± 0.40	9.15 ± 0.60	9.99	0.000	43.81 ± 2.68	32.55 ± 1.3	14.70	0.000
4 wk	8.77 ± 0.83	7.62 ± 0.84	2.63	0.017	44.41 ± 3.15	31.97 ± 1.58	13.79	0.000

MMP: Matrix metalloproteinase.

Table 3 Comparison of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 levels in the tears of two groups of patients at different time points

Time	TIMP-1 (ng/mL)				TIMP-2 (ng/mL)
	Group A	Group B	t value	P value	Group A	Group B	t value	P value
Preoperative	5.24 ± 0.13	5.77 ± 0.10	2.34	0.032	4.28 ± 0.15	3.33 ± 0.28	6.13	0.004
1 d	5.25 ± 0.15	5.76 ± 0.12	2.06	0.028	4.22 ± 0.18	3.58 ± 0.34	6.01	0.003
3 d	5.23 ± 0.14	4.89 ± 0.11	2.83	0.027	4.19 ± 0.13	3.71 ± 0.2	5.41	0.007
1 wk	4.57 ± 0.15	4.61 ± 0.23	0.45	0.060	4.28 ± 0.13	3.44 ± 0.36	5.08	0.006
2 wk	4.20 ± 0.13	5.51 ± 0.15	2.75	0.021	4.23 ± 0.18	3.51 ± 0.31	6.51	0.002
3 wk	4.71 ± 0.18	5.50 ± 0.14	5.75	0.005	4.29 ± 0.16	3.50 ± 0.35	6.60	0.004
4 wk	4.70 ± 0.17	5.77 ± 0.13	7.34	0.003	4.19 ± 0.16	3.50 ± 0.37	6.64	0.003

TIMP: Tissue inhibitor of metalloproteinase.

Table 4 Comparison of interleukin-6 and interleukin-20 levels in the tears of two groups of patients at different time points

Time	IL-6 (pg/mL)				IL-20 (pg/mL)
	Group A	Group B	t value	P value	Group A	Group B	t value	P value
Preoperative	42.84 ± 1.49	29.89 ± 1.09	22.33	0.000	579.90 ± 13.89	533.15 ± 10.9	2.78	0.021
1 d	42.77 ± 1.18	30.17 ± 1.11	24.65	0.000	576.82 ± 10.67	535.13 ± 16.38	2.39	0.024
3 d	48.11 ± 2.01	33.79 ± 1.08	19.90	0.000	587.52 ± 7.62	534.28 ± 17.92	2.91	0.037
1 wk	53.85 ± 1.24	42.97 ± 0.52	25.76	0.000	578.75 ± 13.9	539.97 ± 11.95	2.50	0.038
2 wk	49.58 ± 2.02	37.82 ± 1.55	14.63	0.000	579.08 ± 11.15	534.64 ± 13.27	2.67	0.035
3 wk	42.64 ± 1.43	31.44 ± 1.57	16.73	0.000	702.67 ± 35.3	679.85 ± 26.2	2.62	0.032
4 wk	35.82 ± 1.14	29.79 ± 0.81	13.70	0.000	619.55 ± 60.04	570.05 ± 15.94	2.43	0.036

IL: Interleukin.