Epstein-Barr virus-induced infection-associated hemophagocytic lymphohistiocytosis with acute liver injury: A case report

Table 1 Virology assay

Item	May 31	Jun 3
CMV-IgM (AU/mL)	0.081	CMV DNA: < 500 IU/mL
CMV-IgG (AU/mL)	> 1000
EBV-VCA-IgG (AU/mL)	30.900	EB virus DNA: 2.83 × 104 IU/mL
EBV-NA-IgG (AU/mL)	6.790
EBV-EA-IgG (AU/mL)	0.520
EBV-EA-IgA (AU/mL)	0.070
EBV-EA-IgG (AU/mL)	0.520
EBV-VCA-IgM (AU/mL)	0.970
EBV-VCA-IgA (AU/mL)	1.960

CMV: Cytomegalovirus; EBV: Epstein-Barr virus.

Table 2 Ancillary investigations

Item	May 28	June 1	June 3	June 10
White blood cell (× 109/L)	0.25	0.51	12.58	8.76
Neutrophil (%)	8.00	4.00	60.50	73.70
Lymphocyte (%)	88.00	62.70	25.10	20.00
Red blood cell (× 1012/L)	4.48	3.93	4.23	4.14
Hemoglobin (g/L)	126.00	109.00	117.00	117.00
Platelet (× 109/L)	121.00	163.00	195.00	173.00
C-reactive protein (mg/L)	164.96	69.17	46.26	1.55
Procalcitonin (ng/mL)	16.47	1.94	0.86	-
IL-6 (pg/mL)	14.18	-	9.57	-
IL-8 (pg/mL)	90.13	-	43.15	-
Alanine aminotransferase (U/L)	44.50	337.20	154.00	-
Aspartate aminotransferase (U/L)	-	37.70	42.80	-
γ-GT (U/L)	-	221.00	-	-
Erythrocyte sedimentation rate (mm/h)	50.00	102.00	63.00	51.00
Albumin (g/L)	39.80	30.80	28.00	19.10
Total bilirubin (umol/L)	90.50	37.50	-	12.10
Direct bilirubin (umol/L)	-	15.10	-	-
Lactate dehydrogenase (U/L)	137.90	-	934.30	-
Ferritin (ng/mL)	1759.00	> 2000	-	-
Triglyceride (mmol/L)	5.08	-	4.89	-
Prothrombin time (s)	18.90	13.40	14.10	12.70
Activated partial thromboplatin time (s)	42.60	30.90	24.80	24.50
Fibrinogen (g/L)	7.95	9.81	7.26	4.47
D-Dimers (mg/L)	1.69	1.83	2.07	-
International normalized ratio	1.51	1.10	1.15	-
Total lymphocyte (M/L)	-	320.00	-	-
Total-T-lymphocyte (%)	-	62.77	-	-
Helper T cell CD4 (%)	-	44.62	-	-
Cytototoxic T cell CD8 (%)	-	9.23	-	-
CD4/CD8 ratio	-	4.83	-	-
Total lymphocyte B CD19 (%)	-	28.70	-	-
Natural killer cell (CD56 + CD16) (%)	-	18.00	-	-

IL: Interleukin; γ-GT: Gamma-glutamyltransferase.