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©The Author(s) 2023.
World J Clin Cases. Jun 16, 2023; 11(17): 3993-4002
Published online Jun 16, 2023. doi: 10.12998/wjcc.v11.i17.3993
Published online Jun 16, 2023. doi: 10.12998/wjcc.v11.i17.3993
Table 1 Demographic criteria of the study participants (n = 90)
Variable | Control (n = 30), mean ± SD | P value | Late-PE (n = 30), mean ± SD | Early-PE (n = 30), mean ± SD | P value |
Age (yr) | 26.53 ± 1.18 | 0.39 NS | 28.33 ± 1.34 | 28.67 ± 0.99 | 0.39 NS |
BMI (kg/m2) | 24.93 ± 0.34 | 0.77 NS | 26.19 ± 0.29 | 26.96 ± 3.42 | 0.77 NS |
Gestational age (wk) | 34.93 ± 0.20b | 0.0001 | 36.30 ± 0.19a | 30.70 ± 0.34c | 0.0001 |
Systolic BP (mmHg) | 106.00 ± 1.48b | 0.0001 | 152.33 ± 1.71a | 152.33 ± 1.64a | 0.0001 |
Diastolic BP (mmHg) | 82.67 ± 1.85b | 0.0001 | 103.00 ± 1.80a | 102.66 ± 1.79a | 0.0001 |
Mean arterial BP (MAP) | 90.44 ± 1.21b | 0.0001 | 119.44 ±1.69a | 119.22 ± 1.65a | 0.0001 |
AST (IU/L) | 23.09 ± 1.07b | 0.05 | 34.05 ± 5.98a | 27.25 ± 1.41ab | 0.05 |
ALT (IU/L) | 17.82 ± 0.88b | 0.0001 | 30.06 ± 2.75a | 25.17 ± 1.45a | 0.0001 |
Urea (mg/dL) | 25.01 ± 1.32 | 0.84 NS | 25.93 ± 1.56 | 26.21 ± 1.64 | 0.84 NS |
Creatinine (mg/dl) | 0.665 ± 0.02b | 0.0001 | 0.759 ± 0.02a | 0.759 ± 0.02a | 0.0001 |
Albumin in urine | - | 0.19 NS | 460.50 ± 47.06 | 381.66 ± 35.43 | 0.19 NS |
Hemoglobin (g/dL) | 12.68 ± 0.19a | 0.0001 | 11.69 ± 0.19b | 12.02 ± 0.21b | 0.0001 |
Platelets counts × 109 L | 287.60 ± 11.23a | 0.0006 | 182.83 ± 10.48b | 204.90 ± 10.70b | 0.0006 |
Elabela (pg/mL) | 18.36 ± 0.43a | 0.002 | 11.05 ± 0.22b | 7.61 ± 0.19c | 0.002 |
Table 2 Pearson correlation of elabela vs all study participants’ cases (n = 90)
Variable | Pearson correlation | P value |
BMI (kg/m2) | -0.090 | 0.4200 |
Gestational age (wk) | 0.440 | < 0.0001 |
Systolic BP (mmHg) | -0.800 | < 0.0001 |
Diastolic BP (mmHg) | -0.640 | < 0.0001 |
Mean arterial BP | -0.700 | < 0.0001 |
AST (IU/L) | -0.110 | 0.2000 |
ALT (IU/L) | 0.200 | < 0.0030 |
Urea (mg/dL) | 0.004 | 0.9700 |
Creatinine (mg/dL) | -0.310 | < 0.0030 |
Albumin in urine | 0.160 | 0.2000 |
Hemoglobin (g/dL) | 0.290 | < 0.0040 |
Platelets count (× 109/L) | 0.480 | < 0.0001 |
Table 3 Analysis of covariance
Variable | F-ratio | P value |
Body mass index | 0.120 | 0.74 |
Gestational age | 0.990 | 0.32 |
Mean arterial pressure | 0.001 | 0.97 |
Platelets count | 0.020 | 0.65 |
Table 4 Demonstrating the odds ratio, 95% confidence interval and respective P value for serum elabela in early, late-onset pre-eclampsia cases, and healthy controls with regard to serum elabela less 25 centiles
Groups | Odds ratio | 95%CI | P value |
Early-onset PE | 5.21 | 1.28-21.24 | 0.02 |
Late-onset PE | 1.80 | 0.39-8.32 | 0.45 |
Controls | Reference group |
- Citation: Amer Ali E, Nori W, Salman AF, Al-Rawi TSS, Hameed BH, Al-Ani RM. Elabela is a reliable biomarker for predicting early onset preeclampsia: A comparative study. World J Clin Cases 2023; 11(17): 3993-4002
- URL: https://www.wjgnet.com/2307-8960/full/v11/i17/3993.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v11.i17.3993