Treatment with sorafenib plus camrelizumab after splenectomy for primary splenic angiosarcoma with liver metastasis: A case report and literature review

Table 1 Review of case reports published in the last 10 years (2011 to 2021)

Ref.	Report year	Age	Sex	Etiology	Clinical manifestations	Extrasplenic metastasis	Treatment	OS
[23]	2019	80	Female	None	Progressive abdominal pain, weight loss, fatigue, and pallor	Liver and peritoneum metastases	Splenectomy	6 mo
[24]	2019	41	Male	None	Headaches, nausea, vomiting persisting	None	Splenectomy	More than 4 yr
[25]	2019	83	Female	None	Splenomegaly, acute abdominal pain	None	Splenectomy	Less than 6 mo
[26]	2018	55	Female	None	Abdominal pain and hepatosplenomegaly	Liver metastases	Palliative care	NA
[27]	2018	56	Female	None	A spleen nodule wasincidentally diagnosed	None	Splenectomy	More than 18 mo
[28]	2019	42	Male	None	Severe abdominal pain	Liver and lungs metastases	Splenectomy, adjuvant chemoradiotherapy and radiation therapy	23 mo
[29]	2018	35	Female	None	Routine physical examination	Bone and abdominal cavity metastases	Laparoscopic-assisted splenectomy, radiation therapy	57 mo
[30]	2017	49	Male	None	Left upper quadrant abdominal pain, fatigue, insomnia, severe weight loss, nocturnal sweating, and impotence	Peritoneal metastases	Splenectomy and nodal sampling	11 mo
[31]	2016	55	Female	Rudimentary vascular channels	Severe tenderness in the left upper abdominal quadrant	Liver and lungs metastases	Splenectomy and adjuvant chemotherapy (paclitaxel). Second line chemotherapy (ifosfamide/doxorubicin)	NA
[20]	2016	57	Female	None	Gastrointestinal discomfort	Distant metastases	Splenectomy and adjuvant chemotherapy (paclitaxel chemotherapy and pazopanib)	3 yr
[5]	2015	69	Male	Rupture of the spleen	Fatigue, reduced fitness, shortness of breath on exercise, anorexia, and abdominal and back pain, weight loss	Peritoneal tumor deposits	Splenectomy	Less than 1 mo
[19]	2015	45	Female	None	Left upper quadrant and left flank pain	Liver metastases	Splenectomy and adjuvant chemotherapy (paclitaxel)	5 mo
[32]	2014	38	Female	None	Upper abdominal pain and fatigue for about 1 wk	Liver metastasis	Splenectomy	Passed away 3 yr after diagnosis, that is 3 mo after recurrence and liver metastasis
[33]	2015	38	Male	None	Multiple liver masses	Liver metastases	Paclitaxel monotherapy	Less than 3 mo
[34]	2013	54	Male	None	Nonspecific complaints of abdominal pain and loss of appetite	Liver metastases	Splenectomy	3 mo
[34]	2013	77	Female	None	Hematochezia and fatigue	None	Splenectomy	1 mo
[35]	2013	80	Female	None	Syncope, hypotension, vomiting	None	Splenectomy	More than 6 mo
[36]	2013	65	Male	None	Diffuse abdominal pain and distension	Liver metastases	Splenectomy	NA
[37]	2012	70	Male	Hodgkin lymphoma treated with radiotherapy and chemotherapy 30 yr ago	Abdominal pain upper quadrants and jaundice	None	Splenectomy	More than 6 mo
[38]	2012	73	Female	None	Asymptomatic	None	Splenectomy	NA
[38]	2012	23	Female	None	Left upper quadrant pain	None	Splenectomy	NA
[21]	2011	62	Male	None	Acute onset of abdominal pain	Liver metastases	Splenectomy, palliative chemotherapy with etoposide, ifosfamide and doxorubicin	8 mo
[39]	2010	48	Male	None	Left upper quadrant pain and early satiation	Multiple pleural metastases lesions	Splenectomy	NA
[40]	2010	48	Female	None	Weight loss general fatigue, and left hypochondrial pain	Liver metastases	Splenectomy, high-dose chemotherapy with autologous peripheral blood stem cell transplantation, hepatic lobectomy, radiofrequency ablations and administration of recombinant interleukin-2	67 mo
[22]	2010	69	Female	None	Pain in the left upper quadrant of the abdomen, weight loss, progressive shortness of breath	None	Paclitaxel as neoadjuvant therapy, splenectomy and adjuvant chemoradiotherapy	More than 14 mo
[41]	2010	76	Female	None	Left upper abdominal pain	Extensive metastases	Splenectomy	NA
[42]	2010	55	Female	Radiation treatment	NA	None	Splenectomy	More than 4 yr
[43]	2009	15	Male	None	Severe right-upper quadrant abdominal and epigastric pain	Liver, bone, lymph nodes, adrenal metastasis	Splenectomy with hilar lymph node excision, chemotherapy	26.5 mo

NA: Not available; OS: Overall survival.