Case Report
Copyright ©The Author(s) 2022.
World J Clin Cases. Feb 26, 2022; 10(6): 1998-2006
Published online Feb 26, 2022. doi: 10.12998/wjcc.v10.i6.1998
Table 1 Gene, clinical and histological features of different types of progressive familial intrahepatic cholestasis type 3

PFIC1
PFIC2
PFIC3
GeneATP8B1ABCB11ABCB4
ProteinFIC1BSEPMDR3
Serum ALT++++
Serum GGTNormalNormalElevated
Serum TBA++++++
Liver histologyMild cholestasis, mild lobular fibrosisCholestasis, portal fibrosis, giant cell hepatitis, hepatocellular necrosisBile ductular proliferation, inflammatory infiltrate, and biliary fibrosis
Table 2 Liver function throughout the course of the disease

Admission
Discharge
Before pregnancy
13th week of pregnancy
21th week of pregnancy
30th week of pregnancy
ALT (7-41 U/L)1511812852821
AST (13-35U/L)11948381095953
TBil (3.0-21.0 μmol/L)28.114.121.127.421.533.2
DBil (0.1-6.8 μmol/L)16.19.312.015.311.320.8
GGT (7-45U/L)1025459301470199148
ALP (35-100 U/L)226126147223133251
TBA (0.0-10.0 μmol/L)17.219.915.340.552.181.8