Clinical effect of methimazole combined with selenium in the treatment of toxic diffuse goiter in children

Table 1 Comparison of therapeutic effects between the two groups, n (%)

Group	Cases	Markedly effective	Efficient	Invalid	Total effective rate
Joint group	53	25	20	8	45 (84.9)
Traditional group	50	16	14	20	30 (60.0)
χ2					8.062
P value					0.005

Table 2 Comparison of thyroid volume between the two groups before and after treatment (mean ± SD)

Group	Cases	Thyroid volume		t value	P value
		Before treatment	After treatment
Joint group	53	10.25 ± 3.21	6.37 ± 1.06	8.142	0.000
Traditional group	50	10.87 ± 3.15	6.92 ± 1.03	8.449	0.000
t value		0.981	2.693
P value		0.162	0.004

Table 3 Comparison of inflammatory indexes between the two groups before and after treatment (mean ± SD)

Group	Cases	IL-6 (pg/mL)		IL-8 (pg/mL)
		Before treatment	After treatment	Before treatment	After treatment
Joint group	53	13.62 ± 3.56	6.19 ± 1.26a	351.47 ± 23.89	293.62 ± 20.93a
Traditional group	50	12.93 ± 3.17	7.61 ± 1.13a	353.69 ± 23.12	332.78 ± 87.07a
t value		1.03	6.08	0.478	3.179
P value		0.15	0.000	0.316	0.000

^aP < 0.05 vs before treatment.

IL-6: Interleukin-6; IL-8: Interleukin-8.

Table 4 Table 4 Comparison of Serum anti-thyroglobulin, anti-thyroid peroxidase antibody, free thyroxine between the two groups before and after treatment (mean ± SD)

Group	Cases	TRAb (μ/mL)		TPOAb (μ/mL)		FT4 (pmol/L)
		Before treatment	After treatment	Before treatment	After treatment	Before treatment	After treatment
Joint group	53	723.62 ± 124.6	312.77 ± 44.73a	429.48 ± 93.89	238.42 ± 83.08a	56.54 ± 5.56	28.39 ± 4.57a
Traditional group	50	722.93 ± 123.2	617.61 ± 104.05a	429.74 ± 93.97	332.78 ± 87.07a	56.38 ± 5.07	24.63 ± 3.96a
t value		0.028	19.51	1.984	5.63	0.152	4.451
P value		0.488	0.000	0.494	0.000	0.879	0.000

^aP < 0.05 vs before treatment.

TRAb: Serum anti-thyroglobulin; TPOAb: Anti-thyroid peroxidase antibody; FT4: Free thyroxine.

Table 5 Comparison of time taken for free thyroxine to return to normal between the two groups (mean ± SD)

Group	Cases	Time to return to normal (d)
Joint group	53	90.67 ± 8.54
Traditional group	50	123.5 ± 15.14
t value		13.65
P value		0.000