Evaluation of gut dysbiosis using serum and fecal bile acid profiles

doi:10.12998/wjcc.v10.i34.12484

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 10, Issue 34

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (4229)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-2) series, Tables (1-2) series.

Item

Count

PDF

200

WORD

HTML

2230

Figures (1-2)

495

Tables (1-2)

374

Sum=3324

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

314

Download

591

Sum=905

Dec 6, 2022 (publication date) through Apr 12, 2025

Times Cited of This Article

Times Cited (4)

Journal Information of This Article

Publication Name

World Journal of Clinical Cases

ISSN

2307-8960

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

World J Clin Cases. Dec 6, 2022; 10(34): 12484-12493
Published online Dec 6, 2022. doi: 10.12998/wjcc.v10.i34.12484

Table 1 Correlation between the relative abundance of different fecal microbial taxa and serum or fecal deoxycholic acid (DCA)/(DCA + cholic acid) ratio (n = 46)

Fecal microbial taxa	DCA/(DCA+CA)
Fecal microbial taxa	Serum	Feces
Bifidobacterium	0.2136	0.0683
Lactobacillales	-0.5326^a	-0.6830^a
Bacteroides	0.1836	0.3031^c
Prevotella	-0.0342	0.2693
Clostridium cluster IV	0.2282	0.4307^b
Clostridium subcluster XIVa	0.5217^a	0.7659^a
Clostridium cluster IX	0.0710	0.0208
Clostridium cluster XI	-0.0631	-0.0053
Clostridium cluster XVIII	0.0348	-0.0425
Others	-0.0102	-0.0637

^aP < 0.001.

^bP < 0.01.

^cP < 0.05.

DCA: Deoxycholic acid; CA: Cholic acid. Pearson’s correlation coefficients were calculated using serum and feces from 26 healthy controls and 20 patients, including 6 with Crohn’s disease, 6 with ulcerative colitis, 4 with liver cirrhosis, and 4 with other gastrointes- tinal diseases (pancreatic cancer, colon cancer, ischemic small bowel disease, and alcoholic liver disease). This table was summarized from the Inflammatory Bowel Diseases 2018[24].

Table 2 Studies using the bile acid calculated product/(product+substrate) ratio

Ref.	Subjects	Samples	Major findings
Murakami et al[24], 2018	6 with CD, 6 with UC and 26 HCs	Serum feces	DCA/(DCA+CA)↓; LCA/(LCA+CDCA)↓
Monma et al[25], 2022	12 with CDI, 59 without CDI and 46HCs	Serum	DCA/(DCA+CA)↓; LCA/(LCA+CDCA)→
Ushiroda et al[41], 2019	High-fat diet-fed mice	Serum	DCA/(DCA+CA)↑; LCA/(LCA+CDCA)→
Yasukawa et al[42], 2019	Healthy volunteers; Effects of Partially hydrolyzed guar gum (PHGG)	Plasma	DCA/(DCA+CA)↓; LCA/(LCA+CDCA)→
Kasai et al[43], 2022	NAFLD (MF, AF) and 26 HCs	Feces	DCA/(DCA+CA)→; LCA/(LCA+CDCA)→
Misawa et al[44], 2020	Elobixibat treatment	Feces	DCA/(DCA+CA)→; LCA/(LCA+CDCA)→

BA: Bile acid; CD: Crohn's disease; UC: Ulcerative colitis; CDI: Clostridium difficile infection; HCs: Healthy controls; DCA: Deoxycholic acid; CA: Cholic acid; LCA: Lithocholic acid; CDCA: Chenodeoxycholic acid; MF: Mild fibrosis; AF: Advanced fibrosis.

Citation: Monma T, Iwamoto J, Ueda H, Tamamushi M, Kakizaki F, Konishi N, Yara S, Miyazaki T, Hirayama T, Ikegami T, Honda A. Evaluation of gut dysbiosis using serum and fecal bile acid profiles. World J Clin Cases 2022; 10(34): 12484-12493
URL: https://www.wjgnet.com/2307-8960/full/v10/i34/12484.htm
DOI: https://dx.doi.org/10.12998/wjcc.v10.i34.12484