Dynamic changes of estimated glomerular filtration rate are conversely related to triglyceride in non-overweight patients

Table 1 Baseline characteristics of patients

Variables	BMI < 25 (n = 158)	BMI ≥ 25 (n = 44)	Z or χ2	P value
Age (yr)	36.0 (32.0-47.3)	38.0 (32.3-45.8)	-0.098	0.92
Male, n (%)	111 (70.3)	39 (88.6)	6.084	0.01
ALT (U/L)	59.7 (29.3-163.5)	52.6 (36.0-189.6)	-0.684	0.49
AST (U/L)	40.6 (28.2-92.5)	44.0 (25.4-104.3)	-0.222	0.83
TBIL (µmol/L)	14.1 (10.7-20.8)	16.0 (12.3-18.9)	-1.328	0.18
CHOL (mmol/L)	3.9 (3.2-4.4)	3.8 (3.2-4.4)	-0.023	0.98
TG (mmol/L)	0.9 (0.6-1.2)	1.0 (0.7-1.4)	-1.508	0.13
Cr (µmol/L)	69.0 (59.8-81.0)	77.0 (62.0-85.2)	-2.342	0.02
eGFR (mL/(min·1.73 m2)	112.5 (97.0-131.4)	105.9 (96.4.3-133.9)	-0.951	0.18
eGFR categories, n (%)
< 90	22 (13.9)	10 (22.7)
≥ 90	136 (86.0)	34 (77.3)	2.001	0.16
LC, n (%)	27 (17.1)	7 (20.6)	0.034	0.85
Diabetes mellitus, n (%)	4 (2.5)	2 (4.5)	0.484	0.49
Kidney disease, n (%)	1 (0.6)	0 (0)	0.28	0.6
HBV DNA (Log10IU/mL)	5.06 (3.72-6.86)	5.17 (3.2-6.97)	-0.091	0.93
HBeAg, n (%)	112 (70.9)	33 (75.0)	0.288	0.59

Data are presented as proportions, or medians (inter-quartile). The Mann-Whitney U test for quantitative data with non-normal distribution, and Chi-square test for categorical values. BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBil: Total bilirubin; CHOL: Total cholesterol; TG: Triglycerides; Cr: Creatinine; eGFR: Estimate glomerular filtration rate; LC: Liver cirrhosis; HBeAg: Hepatitis B surface antigen.

Table 2 Risk factors for estimate glomerular filtration rate < 90 mL/min·1.73 m² at the 3^rd year (N = 202)

Baseline variables	Univariate analysis			Multivariate analysis
	Odds ratio	95%CI	P value	Odds ratio	95%CI	P value
Age	0.909	0.878-0.941	< 0.01	0.93	0.890-0.971	0.01
Gender (male)	0.576	0.248-1.335	0.2
BMI value	0.949	0.884-1.067	0.38
LC	6.144	2.781-13.574	< 0.01	2.07	0.684-6.265	0.2
ALT	1.001	0.999-1.002	0.57
AST	1	0.998-1.003	0.77
TBIL	0.975	0.956-0.994	0.01	0.989	0.972-1.007	0.24
CHOL	1.149	0.762-1.732	0.51
TG	0.795	0.475-1.332	0.38
eGFR < 90	14.8	6.192-35.376	< 0.01	13.304	5.084-34.812	< 0.01

Data are expressed as odds ratio and 95% confidence intervals. BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBil: Total bilirubin; CHOL: Total cholesterol; TG: Triglycerides; eGFR: Estimate glomerular filtration rate; LC: Liver cirrhosis.

Table 3 Risk factors for estimate glomerular filtration rate < 90 mL/min·1.73 m² at the 3^rd year in non-obese patients (N = 158)

Baseline variables	Univariate analysis			Multivariate analysis
	Odds ratio	95%CI	P value	Odds ratio	95%CI	P value
Age	0.912	0.879-0.946	< 0.01	0.934	0.891-0.979	< 0.01
Gender (male)	0.519	0.209-1.289	0.16
LC	6.937	2.832-16.996	< 0.001	1.823	0.532-6.254	0.34
ALT	1.001	0.998-1.004	0.46
AST	1.001	0.950-0.992	0.59
TBIL	0.971	0.951-0.992	< 0.01	0.989	0.971-1.008	0.25
CHOL	1.021	0.652-1.601	0.93
TG	0.599	0.310-1.158	0.13
eGFR < 90	12.429	4.504-34.392	< 0.01	9.902	3.273-29.955	< 0.01

Data are expressed as odds ratio and 95% confidence intervals. BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBil: Total bilirubin; CHOL: Total cholesterol; TG: Triglycerides; eGFR: Estimate glomerular filtration rate; LC: Liver cirrhosis.

Table 4 Risk factors for estimate glomerular filtration rate < 90 mL/min·1.73 m² at the 3^rd year in obese patients (N = 44)

Baseline variables	Univariate analysis			Multivariate analysis
	Odds ratio	95%CI	P value	Odds ratio	95%CI	P value
Age	0.892	0.811-0.980	0.02	0.884	0.773-1.010	0.07
Gender (male)	0.965	0.095-1.412	0.27
LC	3.875	0.685-21.934	0.13
ALT	1	0.997-1.005	0.95
AST	0.999	0.942-1.003	0.71
TBIL	0.997	0.942-1.005	0.92
CHOL	1.967	0.710-5.452	0.19
TG	1.337	0.402-4.717	0.61
eGFR < 90	0.027	0.004-0.192	< 0.01	0.025	0.003-0.235	0.01

Data are expressed as odds ratio and 95% confidence intervals. BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBil: Total bilirubin; CHOL: Total cholesterol; TG: Triglycerides; eGFR: Estimate glomerular filtration rate; LC: Liver cirrhosis.