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©The Author(s) 2022.
World J Clin Cases. Jan 21, 2022; 10(3): 790-801
Published online Jan 21, 2022. doi: 10.12998/wjcc.v10.i3.790
Published online Jan 21, 2022. doi: 10.12998/wjcc.v10.i3.790
Table 1 Clinical characteristics of the study population
Characteristics | All patients (n = 412) | |
Number (n) | Percent (%) | |
Age, yr | ||
Median | 63 | |
Range | 18-88 | |
< 65 | 188 | 45.6 |
≥ 65 | 224 | 54.4 |
Gender | ||
Female | 190 | 46.1 |
Male | 222 | 53.9 |
BMI | ||
Median | 27.5 | |
Range | 17.6-59.8 | |
< 28 | 191 | 46.4 |
≥ 28 | 217 | 52.7 |
TMB, mut/Mb | ||
Median | 2.5 | |
Range | 0-51.6 | |
≤ 3.1 | 239 | 58.0 |
> 3.1 | 140 | 34.0 |
CA19-9 | ||
< 40 U/mL | 121 | 29.4 |
≥ 40 U/mL | 192 | 46.6 |
Chronic viral hepatitis | ||
Negative | 379 | 92.0 |
Positive | 33 | 8.0 |
Tumor resection | ||
Resected | 203 | 49.3 |
Unresected | 209 | 50.7 |
Tumor grade | ||
Well differentiated | 15 | 3.6 |
Moderately differentiated | 231 | 56.1 |
Poorly differentiated | 146 | 35.4 |
Disease progression | ||
Solitary liver tumor | 148 | 35.9 |
Multifocal liver disease | 86 | 20.9 |
Metastatic disease | 178 | 43.2 |
Smoking status | ||
Never smoked | 202 | 49.0 |
Former smoker | 166 | 40.3 |
Current smoker | 41 | 10.0 |
Table 2 Grouping analysis of the relationship between tumor mutation burden and overall survival
Median survival (mo) | Log-rank test | |||
TMB-high | TMB-low | HR | P value | |
Tumor grade | ||||
Well differentiated | - (n = 5) | 56.1 (n = 10) | 0.64 (0.15-2.27) | 0.582 |
Moderately differentiated | 26.5 (n = 79) | 42.5 (n = 134) | 1.46 (1.02-2.08) | 0.026 |
Poorly differentiated | 20.2 (n = 52) | 29.8 (n = 82) | 1.72 (1.11-2.66) | 0.007 |
Disease progression | ||||
Solitary liver tumor | 55.1 (n = 44) | 69.4 (n = 93) | 1.42 (0.85-2.38) | 0.140 |
Multifocal liver disease | 24.4 (n = 31) | 40.6 (n = 46) | 1.85 (1.00-3.43) | 0.026 |
Metastatic disease | 15.5 (n = 65) | 15.8 (n = 100) | 1.17 (0.83-1.66) | 0.357 |
Tumor resection | ||||
Resected | 36.6 (n = 67) | 61.5 (n = 127) | 1.77 (1.17-2.66) | 0.002 |
Unresected | 17.5 (n = 73) | 17.7 (n = 112) | 1.13 (0.81-1.59) | 0.461 |
Table 3 Univariable and multivariable analysis of overall survival
Univariable | Multivariable | |||||
HR | 95%CI | P value | HR | 95%CI | P value | |
Age, yr | ||||||
< 65 | ||||||
≥ 65 | 0.96 | 0.76-1.21 | 0.7286 | 1.16 | 0.84-1.61 | 0.3662 |
Gender | ||||||
Female | ||||||
Male | 1.27 | 1.00-1.61 | 0.0424 | 1.27 | 0.94-1.72 | 0.1145 |
BMI | ||||||
< 28 | ||||||
≥ 28 | 0.80 | 0.63-1.00 | 0.0536 | 0.84 | 0.62-1.132 | 0.2517 |
TMB, mut/Mb | ||||||
Low (≤ 3.1) | ||||||
High (> 3.1) | 1.47 | 1.13-1.91 | 0.002 | 1.43 | 1.05-1.96 | 0.0240 |
CA19-9 | ||||||
< 40 U/mL | ||||||
≥ 40 U/mL | 1.79 | 1.37-2.33 | < 0.0001 | 1.78 | 1.28-2.46 | 0.0005 |
Chronic viral hepatitis | ||||||
Negative | ||||||
Positive | 1.19 | 0.78-1.83 | 0.3667 | 1.72 | 1.01-2.95 | 0.0468 |
Tumor resection | ||||||
Resected | ||||||
Unresected | 3.09 | 2.39-3.99 | < 0.0001 | 2.58 | 1.72-3.88 | < 0.0001 |
Tumor grade | ||||||
Well differentiated | ||||||
Moderately differentiated | 2.01 | 1.19-3.39 | 0.0471 | 1.08 | 0.49-2.38 | 0.8489 |
Poorly differentiated | 2.26 | 1.34-3.80 | 0.0211 | 1.15 | 0.52-2.57 | 0.7298 |
Disease progression | ||||||
Solitary liver tumor | ||||||
Multifocal liver disease | 2.26 | 1.53-3.36 | < 0.0001 | 1.47 | 0.86-2.52 | 0.1587 |
Metastatic disease | 3.79 | 2.87-5.01 | < 0.0001 | 2.55 | 1.55-4.20 | 0.0002 |
Smoking status | ||||||
Never smoked | ||||||
Former smoker | 1.02 | 0.80-1.31 | 0.8591 | 0.94 | 0.69-1.29 | 0.7077 |
Current smoker | 1.03 | 0.69-1.52 | 0.8971 | 1.64 | 0.98-2.73 | 0.0587 |
- Citation: Song JP, Liu XZ, Chen Q, Liu YF. High tumor mutation burden indicates a poor prognosis in patients with intrahepatic cholangiocarcinoma. World J Clin Cases 2022; 10(3): 790-801
- URL: https://www.wjgnet.com/2307-8960/full/v10/i3/790.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v10.i3.790