Metastasis to the thyroid gland from primary breast cancer presenting as diffuse goiter: A case report and review of literature

Table 1 Characteristics of metastasis to the thyroid gland from primary breast cancer in reports from 2000 to 2020

Ref.	Study year	No of patients	Sex	Age	Primary tumor	Other recurrence	Time interval (mo)	Presentation	Treatment	Response	Follow-up (mo)
Wang et al [8], 2020	-	1	F	58	Mucinous	Nil	156	Neck swelling	Thyroidectomy	Stable	9 alive
Durmo et al[10], 2019	-	1	F	72	Ductal	-	-	Abnormality of 18F-FDG PET/CT	-	-	-
Pensabene et al[11], 2018	2011-2015	1	F	64	Lobular	Nil	6	Multinodular goiter	Hemithyroidectomy	Recurrence in bone	32
Zhou et al[12], 2017	2005-2015	8	F	48	Poorly differentiated	Chest wall	84	-	Chemotherapy	PR	14 alive
				59	Invasive	Chest wall	24		Chemotherapy	CR	5 alive
				57	Invasive	LN, lung	108		Chemotherapy	CR	21 alive
				67	Ductal	Nil	74		Chemotherapy	CR	4 alive
				48	Ductal	Lung	120		Total thyroidectomy	CR	15 alive
				52	Ductal	Nil	6		Hemithyroidectomy	CR	45 alive
				69	Poorly differentiated	Nil	60		Total thyroidectomy	CR	38 alive
				43	Medullary	LN	84		Chemotherapy	PR	30 alive
Plonczak et al[13], 2017	2004-2017	1	F	62	Ductal	Lung, bone	144	Neck swelling	Total thyroidectomy	Stable	14 alive
Magers et al[14], 2016	-	1	F	37	Ductal	Brain, bone	72	-	-	-	-
Liu et al[15], 2014	2007-2009	1	F	47	Ductal	Nil	24	Enlarged thyroid with diffuse microcalcification	-	-	-
Nguyen et al[16], 2013	-	1	F	67	Lobular	Nil	48	-	-	-	-
Lacka et al[17], 2012	-	1	F	54	Ductal + lobular	Bone, suprarenal gland	168	Multinodular goiter	Total thyroidectomy	-	36 alive
Kolarevic et al[18], 2012	2002-2011	1	F	54	Ductal + lobular	Nil	84	Palpable thyroid nodules	Chemotherapy and hemithyroidectomy	PR	24 alive
Leboeuf et al[20], 2006	1989-2005	1	F	59	Ductal	Mediastinal, lung, LN, adrenal	168	Unpalpable thyroid nodules	Total thyroidectomy		12
Skowronska Jozwiak et al[19], 2010	-	2	F	49	Lobular	Nil	0	Palpable thyroid nodules	Total thyroidectomy	-	-
				65	-	lung	48	Palpable thyroid nodules	Disqualified	-	-
Peteiro et al [23], 2005	-	1	F	42	Ductal	Nil	0	Palpable thyroid nodules	Hemithyroidectomy	-	-
Garrido et al [21], 2006	2003-2005	1	F	43	-	Nil	24	Palpable thyroid nodules, hoarseness, dysphonia, dysphagia	Total thyroidectomy and chemotherapy	Carcinomatous lymphangitis	1
Cichoń et al[22], 2006	1993-2005	1	F	50	-	Nil	120	Multinodular goiter	Total thyroidectomy	Stable	24 alive
Owens et al[24], 2005	-	1	F	64	Invasive	Nil	60	Neck swelling and pain	Chemotherapy	-	-
Kim et al[7], 2005	1997-2003	5	F	36	Ductal	LN, lung	18	Palpable thyroid nodules	Chemotherapy	Stable	6 alive
				34	Ductal	Lung, scalp	25	Multinodular goiter	Chemotherapy	Stable	17 alive
				44	Ductal	Nil	37	Palpable thyroid nodules	Chemotherapy	Stable	4 alive
				55	Ductal	Lung, parotid gland	68	Multinodular goiter	Chemotherapy	PD	26
				45	Ductal	Neck LN, lung, bone	85	Palpable thyroid nodules	Chemotherapy	Stable	8 alive
Wood et al[26], 2004	1985–2002	1	F	72	Invasive	Nil	180	-	Total thyroidectomy	Stable	36 alive
Mistelou et al[9], 2019	1998-2013	3	F	62	Ductal	Pleura, chest wall, lung, heart, liver	-	-	-	-	-
				76	Ductal	Pleura, bone, chest wall, lung, adrenal	-	-	-	-	-
				76	Lobular	Chest wall, pleura, lung, bone, liver	-	-	-	-	-
Ridder et al[28], 2003	-	1	F	-	Lobular	-	-	-	Hemithyroidectomy	-	19
Chung et al[30], 2001	1995-2000	6	F	49		Lung, bone
				61		Lung
				51		Lung, bone, liver
				32		Lung, liver
				22		Bone, peritoneum
				33		Lung
Bult et al[31], 2000	-	1	F	64	Invasive	Nil	144	Palpable thyroid nodules	Chemotherapy + radiation	No response	10
Loo et al[29], 2003	-	1	F	52	Ductal	bone	96	Palpable thyroid nodules	Chemotherapy	Stable	24 alive
Gong et al[25], 2005	-	1	F	57	Metaplastic	Nil	24	Palpable thyroid nodules, hoarseness, dysphasia	-	-	-
Jimenez et al[27], 2004	-	1	F	37	-	Nil	36	Acute thyroiditis	Total thyroidectomy	Stable	7 alive
Current study	2015-2020	1	F	49	Ductal	neck LN	36	Enlarged homogeneous thyroid	Chemotherapy	Stable	6 alive

LN: Lymph node.