Analysis of the successful clinical treatment of 140 patients with parathyroid adenoma: A retrospective study

Table 1 Distribution of clinical symptoms in 140 patients with parathyroid adenoma

Clinical symptoms	Number of patients, n (%)
Urinary system symptoms	51 (36.4)
Skeletal system symptoms	28 (20.0)
Digestive system symptoms	23 (16.4)
Neuromuscular system symptoms	8 (5.7)
Psychiatric symptoms	4 (2.9)
Asymptomatic	26 (18.6)

Table 2 Preoperative laboratory tests of 140 patients with parathyroid adenoma

Laboratory test	Mean/median	Reference range
Blood calcium	2.84 ± 0.34 mmol/L	2.2-2.7 mmol/L
Blood phosphorus	0.84 ± 0.29 mmol/L	0.85-1.51 mmol/L
PTH	201.0 pg/mL (99.8 pg/mL)	12-88 pg/mL
ALP	97 U/L (20.1 U/L)	45-125 U/L
BUN	5.20 ± 1.74 mmol/L	2.86-7.14 mmol/L
Cr	64.81 ± 30.55 μmol/L	57-97 μmol/L
UA	345.95 ± 94.73 μmol/L	208-428 μmol/L
24 h-UCa	8.99 ± 3.49 mmol/24 h	0-7.5 mmol/24 h
24 h-UP	15.70 ± 7.46 mmol/24 h	12.9-42.0 mmol/24 h

PTH: Parathyroid hormone; ALP: Alkaline phosphatase; BUN: Blood urea nitrogen; Cr: Creatinine; UA: Uric acid; 24 h-UCa: 24 hour urinary calcium; 24 h-UP: 24 hour urinary phosphorus.

Table 3 Positive detection rate of imaging examinations in 140 patients with parathyroid adenoma

Imaging methods	Number of inspected cases	Exact number of patients	Positive detection rate
Ultrasound	140	120	85.7%
Tc-99m MIBI SPECT/CT	140	130	92.9%
CT scan with contrast	54	41	75.9%
MRI with contrast	30	23	76.7%
Ultrasound + Tc-99m MIBI SPECT/CT	140	135	96.4%

Tc-99m MIBI: Technetium-99 m sestamibi; SPECT/CT: Single-photon emission computed tomography/computed tomography; MRI: Magnetic resonance imaging.

Table 4 Distribution of surgical methods in the 140 patients with parathyroid adenoma

Surgical procedures	Number of patients, n (%)
Unilateral parathyroid exploration	121 (86.4)
Bilateral parathyroid exploration	19 (13.6)

Table 5 Distribution of location in 140 patients with parathyroid adenoma and the correlation between the findings in the different diagnostic tools and the lesion position

Position	Number of patients, n (%)	Ultrasound	Tc-99m MIBI SPECT/CT	CT scan with contrast	MRI with contrast	Ultrasound + Tc-99m MIBI SPECT/CT
Upper left PA	19 (13.6)	18/19	15/19	6/7	5/5	18/19
Lower left PA	51 (36.4)	45/51	50/51	14/16	5/6	50/51
Upper right PA	13 (9.3)	12/13	11/13	4/5	4/4	12/13
Lower right PA	45 (32.1)	40/45	44/45	12/14	4/5	44/45
Upper mediastinal ectopic PA	3 (2.1)	0/3	3/3	2/3	2/3	3/3
Intrathyroidal ectopic PA	1 (0.7)	1/1	1/1	0/1	0/1	1/1
Upper left PA combined with upper right PA	6 (4.3)	3/6	5/6	3/6	3/4	5/6
Upper left PA combined with lower left PA	1 (0.7)	1/1	0/1	0/1	0/1	1/1
Upper right PA combined with lower right PA	1 (0.7)	0/1	1/1	0/1	0/1	1/1

Tc-99m MIBI: Technetium-99m sestamibi; SPECT/CT: Single-photon emission computed tomography/computed tomography; MRI: Magnetic resonance imaging; PA: Parathyroid adenoma.

Table 6 Postoperative complications in 140 patients with parathyroid adenoma

Complications	Number of cases, n (%)
Hypocalcemia	21 (15.0)
Hoarse voice	1 (0.7)
Hypoparathyroidism	19 (13.6)
Bleeding or hematoma in the surgical area	0 (0)