Malignant transformation of biliary adenofibroma combined with benign lymphadenopathy mimicking advanced liver carcinoma: A case report

Table 1 Timeline of management

Time (day)	Event
1	Outpatient evaluation
4	Hospitalization
6	Found liver mass by CT
11	PET-CT
13	Core needle biopsy of the liver mass
15	Cervical lymph node biopsy
25	Surgery
36	Discharge

CT: Computed tomography; PET: Positron emission tomography.

Table 2 Biliary adenofibroma with malignant transformation of the liver, review of the literature

No.	Ref.	Age	Sex	Tumor location	Size (cm)	Treatment	Ki67, %	p53	Outcome	Additional information
1	Akin et al[8], 2002	25	M	Right hepatic lobe	20	Right hepatectomy	NA	NA	Hepatic recurrence and pulmonary metastasis after 3 yr
2	Kai et al[12], 2012	40	M	Right hepatic lobe	7	Right hepatectomy	5-10	NA	No recurrence at 8-mo follow-up
3	Nguyen et al[13], 2012	53	F	Segment IVb	6.5	Resection of segments III/IV	NA	NA	No recurrence after 12 mo
4	Tsutsui et al[5], 2014	69	F	Segment VI	3.5	Partial hepatectomy	10-15	Focally positive	No recurrence at 4-yr follow-up	Dysplastic changes
5	Thompson et al[4], 2016	71	M	Left hepatic lobe	14.5	Left hepatectomy	NA	NA	No recurrence of liver tumor for 9 yr	Moderatlely-differentiated adenocarcinoma
6	Thompson et al[4], 2016	71	M	Caudate lobe	6.3	Codate lobectomy	NA	NA	No recurrence at 1-mo follow-up	Well-differentiated adenocarcinoma
7	Godambe et al[6], 2016	71	F	Segments II, III and IVa	5.7	Left hepatectomy	50	Positive	NA	Microinvasive carcinoma
8	Thai et al[14], 2016	77	M	Segment II	4	Left hepatectomy	NA	NA	NA	Cholangiocarcinoma arising from BAF
9	Kaminsky et al[2], 2017	37	F	Segment V	4.5	Partial hepatectomy	50	Negative	No recurrence at 4-mo follow-up	Cholangiocarcinoma arising from BAF
10	Chua et al[7], 2018	66	F	Segment IVb	6	Wedge resection	2	Positive	No recurrence at 4-mo follow-up	Cholangiocarcinoma arising from BAF
11	Sturm et al[15], 2019	63	F	Segment IVa	6.3	Left hepatectomy	20-30	Focally positive	No recurrence at 24-mo follow-up
12	Alshbib et al[9], 2022	63	M	Segments IVb and V	15.5	Resection of segments IVb and V	25	Weak	Hepatic recurrence 3 mo
13	Current report	51	F	Segments VII and VIII	7.5	Partial hepatectomy	5	Negative	No recurrence at 12-mo follow-up

BAF: Biliary adenofibroma; NA: Not available.