Ovarian mucinous tumor with mural nodules of anaplastic carcinoma: Three case reports

Table 1 Immunohistochemical and molecular results

	Case 1		Case 2		Case 3
	Epithelium	Nodule	Epithelium	Nodule	Epithelium	Nodule
Immunohistochemical
AE1/CK7	+	+	+	+	+	+
Vim	-	+	-	+	-	+
ER/PR	-	-	-	-	-	-
Pax8	Focally+	-	+	+	+	+
TP53	WT	WT	WT	WT	WT	WT
PTEN	+	+	+	+	-	-
Hotspot mutations
KRAS	WT	p.G12S/D	p.G12S/D	WT	p.G13D	p.G13D
NRAS	WT	WT	WT	WT	WT	WT
BRAF	WT	WT	WT	p.V600E/K/R/O	WT	WT

Table 2 Clinicopathological features of three cases

Case	Age in yr	Mucinous tumor	Size of nodule in cm3	Nodule type	FIGO stage	Prognosis
1	25	MA	4 × 4 × 4	SAAC	Ic	DT (12 mo)
2	60	BMC	3 × 3 × 3	AC	Ia	DT (18 mo)
3	55	MA	1 × 1 × 1	AC	IIIc	DT (14 mo)

MA: Mucinous adenocarcinoma; BMC: Borderline mucinous cystadenoma; SAAC: Sarcoma like and anaplastic carcinoma; AC: Anaplastic carcinoma; DT: Death from tumor; FIGO: Federation of Gynecology and Obstetrics.