Correlation of magnetic resonance imaging quantitative parameters and apparent diffusion coefficient value with pathological breast cancer

Table 1 Comparison of general information of the two groups of patients, n (%)

Factor	Breast cancer group (n = 108)	Benign group (n = 110)	t/χ2	P value
Age (mean ± SD, yr)	46.1 ± 7.0	47.5 ± 8.4	-1.336	0.183
Body mass index (mean ± SD, kg/m2)	24.6 ± 2.5	24.3 ± 2.6	0.868	0.386
Affected side distribution			0.902	0.342
Left side	58 (53.7)	52 (48.15)
Right	50 (46.3)	58 (53.7)
Hypertension			0.618	0.432
Yes	11 (10.19)	15 (13.89)
No	97 (89.81)	95 (87.96)
Diabetes			2.062	0.151
Yes	6 (5.56)	12 (11.11)
No	102 (94.44)	98 (90.74)
Hyperlipidemia			2.221	0.136
Yes	17 (15.74)	10 (9.26)
No	91 (84.26)	100 (92.59)
Menopause			0.930	0.335
Yes	18 (16.67)	24 (22.22)
No	90 (83.33)	86 (79.63)

Table 2 Comparison of magnetic resonance imaging parameters and apparent diffusion coefficient values between the two groups (mean ± SD)

Groups	Ktrans (min-1)	Kep (min-1)	Ve	ADC (× 10-3 mm2/s)
Breast cancer group (n = 108)	0.481 ± 0.113	0.577 ± 0.120	0.764 ± 0.170	0.741 ± 0.184
Benign group (n = 110)	0.264 ± 0.096	0.408 ± 0.113	0.528 ± 0.150	1.109 ± 0.241
t value	15.290	10.707	10.874	-12.655
P value	0.000	0.000	0.000	0.000

ADC: Apparent diffusion coefficient.

Table 3 Comparison of magnetic resonance imaging parameters and apparent diffusion coefficient values in breast cancer patients with different immunostaining and histochemical results (mean ± SD)

Express the situation	n	Ktrans (min-1)	Kep (min-1)	Ve	ADC (× 10-3 mm2/s)
ER
Positive	74	0.462 ± 0.105	0.563 ± 0.112	0.740 ± 0.166	0.713 ± 0.170
Feminine	34	0.522 ± 0.100	0.607 ± 0.109	0.816 ± 0.154	0.802 ± 0.168
t value		-2.698	-1.912	-2.259	-2.536
P value		0.008	0.059	0.026	0.013
PR
Positive	62	0.468 ± 0.108	0.542 ± 0.115	0.751 ± 0.165	0.721 ± 0.180
Feminine	46	0.499 ± 0.111	0.624 ± 0.116	0.782 ± 0.158	0.768 ± 0.178
t value		-1.458	-3.651	-0.983	-1.348
P value		0.148	0.000	0.328	0.180
HER-2
Positive	34	0.461 ± 0.107	0.621 ± 0.116	0.713 ± 0.166	0.719 ± 0.181
Feminine	74	0.490 ± 0.110	0.557 ± 0.109	0.787 ± 0.162	0.751 ± 0.178
t value		-1.283	2.777	-2.188	-0.863
P value		0.202	0.006	0.031	0.390

ADC: Apparent diffusion coefficient; ER: Estrogen receptor; PR: Progesterone receptor; HER-2: Human epidermal growth factor receptor-2.

Table 4 Comparison of magnetic resonance imaging parameters and apparent diffusion coefficient values in breast cancer patients with different prognosis (mean ± SD)

Recurrence	n	Ktrans (min-1)	Kep (min-1)	Ve	ADC (× 10-3 mm2/s)
Relapse	22	0.457 ± 0.111	0.528 ± 0.109	0.698 ± 0.155	0.663 ± 0.181
No recurrence	86	0.487 ± 0.107	0.590 ± 0.112	0.781 ± 0.165	0.761 ± 0.176
t value		-1.165	-2.329	-2.130	-2.317
P value		0.247	0.022	0.035	0.022

ADC: Apparent diffusion coefficient.

Table 5 The value of magnetic resonance imaging parameters and apparent diffusion coefficient values in predicting patient recurrence

Index	Critical value	AUC	Sensitivity (%)	Specificity (%)	Missed diagnosis rate (%)	Misdiagnosis rate (%)
Kep (min-1)	0.561	0.599	65.19	55.40	34.81	44.60
Ve	0.725	0.527	58.04	51.06	41.96	48.94
ADC (×10-3 mm2/s)	0.718	0.739	71.57	61.09	28.43	38.91
ADC + Kep + Ve	-	0.858	83.67	77.18	16.33	22.82

ADC: Apparent diffusion coefficient; AUC: Area under the curve.