Apheresis: A cell-based therapeutic tool for the inflammatory bowel disease

Table 1 Assessment of Crohn’s Disease severity using the CDAI tool[10]

Liquid stools per 7 d
Well-being (scored as 0 = generally well, 1 = slightly under par, 2 = poor, 3 = very poor, 4 = terrible)
Abdominal pain (None = 0; Intermediate = 1 or 2; Severe = 3)
Abdominal mass
Use of anti-diarrheal agents
Presence of extra-intestinal complications:
Arthritis/arthralgia
Iritis or uveitis
Skin or mouth lesions
Peri-anal disease
Other-fistula
Fever > 37.8°C (in the past week)
Hematocrit value
% Deviation from standard body weight

Table 2 Structural details of adacolumn for Granulocyte-monocyte apheresis

Name	Material
Column volume	335 mL
Cell adsorbing carriers	Cellulose acetate beads
Bead’s dimension and quantity	2 mm diameter, 220 g weight, 35000 pieces
Body	Polycarbonate
Saline volume	130 mL

Table 3 Mayo score for ulcerative colitis

Score	Stool frequency (stools/day more than normal)	Rectal bleeding	Mucosal appearance at endoscopy	Physician’s assessment
0	Normal	No blood seen	Normal/inactive disease	Normal
1	1-2	Visible blood in stool < 50% of time	Mild disease	Mild
2	3-4	Visible blood with stool in > 50%	Moderate disease	Moderate
3	> 4	Passing blood	Severe disease	Severe

Total scores range from 0 to 12, with higher scores indicating increased severity of the disease[39].