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©The Author(s) 2022.
World J Clin Cases. Jan 14, 2022; 10(2): 563-575
Published online Jan 14, 2022. doi: 10.12998/wjcc.v10.i2.563
Published online Jan 14, 2022. doi: 10.12998/wjcc.v10.i2.563
Table 1 Prevalence of organic disease according to clinical factors and alarm symptoms (n = 730), n (%)
Characteristics | IBS (n = 654) | Organic disease (n = 76) | P value |
Female | 307 (46.94) | 27 (35.53) | 0.059 |
Onset age (yr)1 | 0.682 | ||
> 50 | 268 (40.98) | 33 (43.42) | |
≤ 50 | 386 (59.02) | 43 (56.58) | |
BMI (kg/m2) | 0.360 | ||
< 18.5 | 37 (5.66) | 1 (1.32) | |
18.5-23.9 | 357 (54.59) | 45 (59.21) | |
24.0-27.9 | 212 (32.42) | 26 (34.21) | |
≥ 28 | 48 (7.34) | 4 (5.26) | |
Marital status | 0.014 | ||
Married | 592 (90.52) | 60 (78.95) | |
Never married | 46 (7.03) | 11 (14.47) | |
Divorced | 3 (0.46) | 1 (1.32) | |
Widowed | 13 (1.99) | 4 (5.26) | |
Educational level | 0.446 | ||
Elementary | 88 (13.46) | 13 (17.11) | |
Junior high school | 176 (26.91) | 14 (18.42) | |
High school | 153 (23.39) | 19 (25.00) | |
University or technical college | 218 (33.33) | 29 (30.86) | |
Postgraduate | 19 (2.91) | 1 (1.32) | |
Alcohol use | 0.394 | ||
Almost not | 488 (74.62) | 52 (68.42) | |
Previous | 45 (6.88) | 5 (6.58) | |
At present | 121 (18.50) | 19 (25.00) | |
Tobacco use | 0.102 | ||
Almost not | 456 (69.72) | 44 (57.89) | |
Previous | 49 (7.49) | 7 (9.21) | |
At present | 149 (22.78) | 25 (32.89) | |
Exercise time | 0.406 | ||
< 0.5 h/d | 154 (23.55) | 24 (31.58) | |
≥ 0.5 h/d | 183 (27.98) | 21 (27.63) | |
≥ 1 h/d | 139 (21.25) | 12 (17.11) | |
≥ 2 h/d | 178 (27.22) | 19 (25.00) | |
History of GI infection | 72 (11.01) | 6 (7.89) | 0.405 |
Poor sleep quality | 236 (36.09) | 26 (34.21) | 0.747 |
Dietary factor | 0.900 | ||
Raw or cold food | 131 (20.03) | 17 (22.37) | |
Spicy food | 258 (39.45) | 37 (48.68) | |
Lipid food | 119 (18.20) | 18 (23.68) | |
Milk and dairy products | 95 (14.53) | 9 (11.84) | |
Animal protein | 32 (4.89) | 4 (5.26) | |
FODMAP diet | 103 (15.75) | 12 (15.79) | |
Psychological self-rating scale2 | |||
Anxiety | 0.507 | ||
No | 207 (71.13) | 26 (70.27) | |
Mild | 52 (17.87) | 5 (13.51) | |
Moderate | 27 (9.28) | 6 (16.22) | |
Severe | 5 (1.72) | 0 (0) | |
Depression | 0.672 | ||
No | 184 (63.23) | 26 (70.27) | |
Mild | 53 (18.21) | 4 (10.81) | |
Moderate | 43 (14.78) | 5 (13.51) | |
Severe | 11 (3.78) | 2 (5.41) | |
Medical expenses (RMB) | 0.197 | ||
< 500 yuan | 120 (18.35) | 17 (22.37) | |
500-1000 yuan | 174 (26.61) | 13 (17.11) | |
1000-3000 yuan | 138 (21.10) | 16 (21.05) | |
3000-5000 yuan | 74 (11.31) | 6 (7.89) | |
≥ 5000 yuan | 148 (22.63) | 24 (31.58) | |
Rectal bleeding1 | 115 (17.58) | 20 (26.32) | 0.063 |
Fecal occult blood1 | 75 (11.47) | 18 (23.68) | 0.003 |
Unintended weight loss (kg)1,3 | 0.003 | ||
Without | 507 (77.52) | 47 (61.84) | |
< 2.5 | 68 (10.40) | 16 (21.05) | |
2.5-5.0 | 40 (6.12) | 7 (9.21) | |
5.0-7.5 | 35 (5.35) | 3 (3.95) | |
≥ 7.5 | 4 (0.61) | 3 (3.95) | |
Anemia1 | 37 (5.66) | 11 (14.47) | 0.007 |
Fever1 | 17 (2.60) | 1 (1.32) | 0.770 |
Nocturnal symptoms1 | 164 (25.08) | 17 (22.37) | 0.605 |
Family history of IBD, CRC or celiac disease1 | 55 (8.41) | 5 (6.58) | 0.582 |
Table 2 Multivariate analysis for clinical factors and alarm symptoms1
Characteristics | OR (95%CI) | P value | Partial regression coefficient |
Female (ref male) | 0.560 (0.330, 0.949) | 0.031 | -0.580 |
Marital status | 0.030 | ||
Married | — | — | — |
Never married | 2.499 (1.199, 5.209) | 0.015 | 0.916 |
Divorced | 1.184 (0.088,15.956) | 0.899 | 0.169 |
Widowed | 3.260 (0.964,11.029) | 0.057 | 1.182 |
Anemia (ref absence) | 2.825 (1.273, 6.267) | 0.011 | 1.038 |
Fecal occult blood (ref absence) | 1.940 (1.041, 3.613) | 0.037 | 0.663 |
Unintended weight loss (kg)2 | 0.009 | ||
Without | — | — | — |
< 2.5 | 2.389 (1.255, 4.548) | 0.008 | 0.871 |
2.5-5.0 | 1.868 (0.751, 4.642) | 0.179 | 0.625 |
5.0-7.5 | 0.904 (0.263, 3.110) | 0.872 | -0.101 |
≥ 7.5 | 8.027 (1.638,39.335) | 0.010 | 2.083 |
Table 3 Prevalence of organic disease according to number of alarm symptoms
Number of alarm symptoms | Number of patients (n = 730) | Patients with organic disease, n (%) | P value |
0 | 180 | 15 (8.33) | 0.013 |
1 | 250 | 21 (8.40) | |
2 | 180 | 20 (11.11) | |
3 | 91 | 12 (13.19) | |
4 | 19 | 2 (10.53) | |
5 | 7 | 3 (42.86) | |
6 | 3 | 2 (66.67) |
Table 4 Utility of alarm symptoms for identifying organic disease
Alarm symptoms | PPV (%) |
Onset age > 50 yr | 10.96 |
Rectal bleeding | 14.81 |
Fecal occult blood | 19.35 |
Unintended weight loss1 | 16.48 |
Anemia | 22.92 |
Fever | 5.56 |
Nocturnal symptoms | 9.39 |
Family history of IBD, CRC or celiac disease | 8.33 |
Anemia + fecal occult blood | 69.23 |
Anemia + unintended weight loss | 38.89 |
Fecal occult blood + unintended weight loss | 30.00 |
Anemia + fecal occult blood + unintended weight loss | 100.00 |
Table 5 The accuracy of alarm symptoms in diagnosing irritable bowel syndrome
Colonoscopy findings | PPV (%) | Missed diagnosis (%) | ||
IBS | Organic disease | |||
Without considering alarm symptoms | 654 | 76 | 89.59 | — |
All alarm symptoms considered | ||||
Absence (predicted IBS) | 165 | 15 | 91.67 | 74.77 |
Presence (predicted organic disease) | 489 | 61 | ||
Certain alarm symptoms considered1 | ||||
Absence (predicted IBS) | 431 | 37 | 92.09 | 34.10 |
Presence (predicted organic disease) | 223 | 39 |
Table 6 Colonoscopy findings in suspected irritable bowel syndrome patients
Colonoscopy findings | Number | Percentage (%) |
Ulcerative colitis | 8 | 1.10 |
Non-IBD and noninfectious colitis | 42 | 5.75 |
CRC | 11 | 1.51 |
Terminal ileitis | 18 | 2.47 |
Total organic diseases | 76 | 10.41 |
- Citation: Yang Q, Wei ZC, Liu N, Pan YL, Jiang XS, Tantai XX, Yang Q, Yang J, Wang JJ, Shang L, Lin Q, Xiao CL, Wang JH. Predictive value of alarm symptoms in Rome IV irritable bowel syndrome: A multicenter cross-sectional study. World J Clin Cases 2022; 10(2): 563-575
- URL: https://www.wjgnet.com/2307-8960/full/v10/i2/563.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v10.i2.563